摘要
目的:系统综述光照疗法的光照时间、光照时长、光照强度、光谱分布等不同光照参数对于阿尔茨海默症患者睡眠障碍的影响,旨在为提高阿尔茨海默症患者的睡眠质量提供参考。方法:全面检索中英文数据库中关于光照疗法对阿尔茨海默症患者睡眠障碍的研究,经2名研究者按照纳入和排除标准独立筛选文献、提取资料、评价文献质量,分别对光照参数进行描述性分析。结果:最终纳入12篇文献,其中随机对照试验8篇,队列研究4篇。光照疗法对光照参数要求较高,上午9:00—11:30或17:00—20:00是一天中最好的光照时间点;每天光照2 h,持续2周以上是有效光照的基础,可以改善患者的睡眠障碍,具有较高的安全性;3 000~8 000 lux的光照强度可以最大程度提高睡眠质量;短波蓝色光和白光可以有效纠正昼夜节律紊乱,但仍需进一步研究。结论:光照时间、光照时长、光照强度、光谱分布都是在光照疗法时需要考虑的因素,目前国内外对于不同光照参数还未有明确的标准,未来需要更多的临床研究进一步探讨不同光照参数对阿尔茨海默症患者睡眠障碍的影响。
Objective:To systematically review the effects of different illumination parameters of light therapy,such as the light timing,light duration,light intensity,and spectral distribution,on helping to improve sleep quality in patients with Alzheimer's Disease.Methods:A comprehensive search of Chinese and English databases on the studies of light therapy on sleep disorders in patients with Alzheimer's Disease was conducted.The studies were selected according to the inclusion and exclusion criteria and were critically evaluated by two reviewers.Data of included studies were extracted,and only descriptive analysis was conducted.Results:Eight randomized controlled trials and 4 cohort studies were included.Previous studies have shown that:a)9:00-11:30 am or 5:00-8:00 pm is the best time of the day to exposure light;b)2 hours of light per day for more than two weeks is the basis for ensuring effective light,and it can improve the sleep disorders of patients and has higher safety;c)the light intensity of 3000-8000 lux can substantially improve the quality of sleep;d)short-wave blue light and white light can effectively correct circadian rhythm disorders,but further research is needed.Conclusion:The settings about the timing,duration,intensity and spectral distribution of the light therapy are the elements that need to be considered.At present,there are no standards for light parameters.Further studies should explore different light parameters of light therapy and observe long-term effects of sleep disorders in patients with Alzheimer's Disease.
作者
李博
李亚杰
王哲
LI Bo;LI Yajie;WANG Zhe(School of Nursing and Health,Henan University,Kaifeng,475004,China)
出处
《中国护理管理》
CSCD
北大核心
2020年第9期1299-1305,共7页
Chinese Nursing Management
关键词
光照疗法
阿尔茨海默症
失智症
睡眠障碍
系统评价
light therapy
Alzheimer's Disease
dementia
sleep disturbances
systematic review
