摘要
目的探讨中国18~44岁成人血清25-羟基维生素D[25(OH)D]浓度与全段甲状旁腺素(iPTH)浓度的关系,初步探索判定该人群维生素D适宜营养状况的阈值。方法从2015年中国成人慢性病与营养监测生物样本库中随机选择18~44岁成年人的样本650例,采用问卷调查收集基本信息(包括年龄、性别、地区类型、季节等),测定研究对象的腰围、身高和体重,以秦岭和淮河划分南北方。采用液相色谱串联质谱法测定血清中25(OH)D含量,采用电化学发光法测定iPTH的含量。采用偏相关分析25(OH)D与iPTH的关系,采用广义相加模型调整年龄、采血季节、体质指数、腰围、性别、纬度等协变量,获得调整后的iPTH’,利用局部加权散点平滑法探索iPTH达到平台期时对应的25(OH)D阈值。结果排除血样质量差的样本后,共检测了623份血清样品中25(OH)D浓度和iPTH浓度(男性293份,女性330份)。男性25(OH)D浓度显著高于女性(P<0.0001);南方样品的25(OH)D浓度高于北方样品(P<0.0001);秋季样品的25(OH)D浓度显著高于春季和冬季样品(P<0.0001);城市低于农村(P=0.018)。当25(OH)D浓度为17.6 ng/mL时iPTH进入平台期,其中男性为16.2 ng/mL,女性为25.6 ng/mL,而低于这个界值时25(OH)D浓度与iPTH浓度呈负相关关系。结论中国18~44岁成年人25(OH)D与iPTH相关关系的阈值因性别而异,维生素D适宜水平的判定界值有待进一步研究。
OBJECTIVE To study the relationship between 25-hydroxyvitamin D[25(OH)D]concentration and intact parathyroid hormone(iPTH)concentration in the Chinese non-clinical population aged 18-44 y,and to explore the threshold value of determining the appropriate nutritional status of vitamin D.METHODS A total of 650 plasma samples of adults aged 18-44 years old were selected from the established biological samples’bank of Chinese Chronic Diseases and Nutrition Survey(CCDNS,2015-2018).Basic information(including age,gender,region type,season,etc.)was collected by questionnaires,and the waist circumference,height and weight of the subjects were determined unified.North and South area was divided by Qinling Mountains and Huaihe River.The serum 25(OH)D concentration was determined by high performance liquid chromatography tandem mass spectrometer,and the iPTH was determined by electronic chemiluminescence method.The relationship of 25(OH)D and iPTH were analyzed by partial correlation analysis,and the threshold of 25(OH)D was analyzed by locally weighted scatter plot smoothing method after adjusting the iPTH by age,season of blood draw,BMI,waist,sex and latitude.RESULTS A total of 623 serum samples(293 male,330 female)of 25(OH)D concentration and iPTH concentration were analyzed after excluding samples with poor blood sample quality.Significant higher 25(OH)D concentration was found in male than female(P<0.0001).And the samples from the southern China had higher 25(OH)D concentration than those from the northern China(P<0.0001).Samples from autumn had higher 25(OH)D concentration than those from spring and winter(P<0.0001).The 25(OH)D concentration of samples from cities was lower than that of rural areas(P=0.018).The inversely relationship between 25(OH)D concentration and iPTH concentration was observed when the 25(OH)D was below 17.6 ng/mL for both sexes.The threshold of 25(OH)D for male was 16.2 ng/mL and it was 25.6 ng/mL for female.CONCLUSION The threshold and the relationship between 25(OH)D and iPTH differs by sex among Chinese adults aged 18-44 y.Further study is needed to evaluate the sex-specific ranges of optimal vitamin D.
作者
胡贻椿
李思燃
柳祯
杨晓光
杨丽琛
Hu Yichun;Li Siran;Liu Zhen;Yang Xiaoguang;Yang Lichen(Key Laboratory of Trace Klement Nutrition NIIKPC,National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050,China)
出处
《卫生研究》
CAS
CSCD
北大核心
2020年第5期699-704,共6页
Journal of Hygiene Research
基金
国家自然科学基金面上项目(No.81872627)
国家卫健委营养标准制定项目(No.20180501)。
关键词
成人
维生素D
液相色谱-质谱法
阈值
全段甲状旁腺素
adult
vitamin D
high performance liquid chromatography tandem mass spectrometer
threshold
intact parthyroid hormone
