摘要
血小板内皮聚集受体1(platelet-endothelial aggregation receptor 1,PEAR1)是一种血小板接触受体,介导血小板-血小板接触诱导的血小板聚集。已发现PEAR1基因多个位点的单核苷酸多态性(single nucleotide polymorphism,SNP)与血小板功能及其对常见抗血小板药物的反应性有关,PEAR1基因DNA甲基化也能够调控血小板功能。但PEAR1基因多态性是否影响心血管疾病患者发生血栓相关事件存在争议。目前暂不推荐根据PEAR1基因多态性指导个体化抗血小板治疗,但PERA1作为潜在的抗血小板药物靶点仍有研究价值。PEAR1在血小板与内皮细胞、白细胞相互作用中影响血栓性疾病发生、发展的机制是值得进一步研究的方向。
Platelet-endothelial aggregation receptor 1(PEAR1)is a platelet contact receptor that mediates platelet aggregation induced by platelet-platelet contact.Lots of single nucleotide polymorphisms(SNPs)in PEAR1 are found to be related to platelet function and platelet reactivity to antiplatelet drugs.DNA methylation of the PEAR1 gene can also regulate platelet function.However,whether the PEAR1 gene polymorphism can affect thrombotic events in patients with cardiovascular diseases remains controversial.It is not recommended that PEAR1 gene polymorphisms be used in guiding individualized antiplatelet therapy,but PERA1 remains a potential target for antiplatelet drugs.The interaction of platelets with endothelial cells and leukocytes via PEAR1 and how the crosstalk affects the development of arterial thrombotic diseases are worthy of further research.
作者
李天瑜
袁晋青
LI Tian-yu;YUAN Jin-qing(Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100037,China)
出处
《中国分子心脏病学杂志》
CAS
2020年第4期3445-3448,共4页
Molecular Cardiology of China
关键词
血小板内皮聚集受体1
血小板
单核苷酸多态性
血小板反应性
Platelet-endothelial aggregation receptor 1
Platelet
Single nucleotide polymorphism
Platelet reactivity
