摘要
在硅橡胶表面制备一种具有抗感染功能的涂层—壳聚糖载铜凝胶涂层。为了克服硅橡胶的生物惰性,在其表面制备涂层,先用逐步化学接枝法对其表面进行活化预处理,然后化学接枝壳聚糖载铜凝胶涂层。对比浸泡前后涂层的形貌,研究了活化预处理对功能化涂层与硅橡胶基体之间结合性能的影响。结果表明,用化学接枝法可在硅橡胶表面生成丰富的活性官能团从而提高了功能化涂层与硅橡胶的结合强度。载铜功能化涂层使硅橡胶导管具有良好的抗菌功能。
In order to solve the infection caused by the indwelling catheter,an anti-infective Cu-bearing chitosan coating was prepared on the silicone rubber surface.But it is difficult to prepare a coating on the surface of silicone rubber due to its biological inertness.Therefore,chemical grafting was used to activate the silicone rubber by the dopamine pretreatment,which provides abundant functional groups on the activated silicone rubber surface.The surface morphology and surface properties of the silicone rubber after surface activation pretreatment were characterized by the active functional groups.Onto which,subsequently,the Cu-bearing chitosan coating could be chemically grafted,and then the surface morphology was compared for the coatings before and after immersion test.The effectiveness of pretreatment process was assessed by the bonding force between the functionalized coating and the silicone rubber.It follows that the abundant functional groups offered by the pretreatment on the activated silicone rubber surface may be beneficial for enhancing the adhesive strength of the functionalized coating to the silicon rub-ber.Thereby,the Cu-bearing chitosan coating makes the silicone rubber catheter have good antibacterial function.
作者
王立蓉
关宏宇
陈姗姗
张炳春
杨柯
WANG Lirong;GUAN Hongyu;CHEN Shanshan;ZHANG Bingchun;YANG Ke(Department of Chemistry,Liaoning University,Shenyang 110036,China;Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China)
出处
《材料研究学报》
EI
CAS
CSCD
北大核心
2020年第8期575-583,共9页
Chinese Journal of Materials Research
基金
国家重点研发计划(2018YFC1105504)
中国科学院青年创新促进会项目(2019194)。
关键词
材料表面与界面
功能涂层
逐步化学接枝法
硅橡胶导管
结合性能
surface and interface of material
functional coating
stepwise chemical grafting
silicone rubber catheter
bonding ability
