摘要
复发性流产(RSA)是生殖育龄期女性的常见疾病,发病原因复杂。目前血栓前状态(PTS)在复发性流产病因研究中备受学者关注。PTS主要分为遗传性和获得性两大类,可以诱发胎盘微血栓形成、绒毛梗死及蜕膜血管纤维素样坏死,使胚胎组织缺血缺氧。临床上西医治疗以免疫及抗凝疗法为主,而上述疗法对妊娠结局的影响尚存在争议并且低分子肝素及抗血小板类药物的长期使用可诱导血小板减少、骨质疏松、出血倾向、过敏、椎骨骨折等副反应,并且可增加胎盘早剥和早产的风险。因此,亟待探索新的治疗办法弥补治疗方案的不足。中医多数以肾虚血瘀型滑胎,依照孕前孕后分期辨证施治,应用补肾活血方药,联合西医抗凝治疗效果显著,具有更广的临床推广价值。
Recurrent spontaneous abortion(RSA)is a common disease in women of reproductive age with complicated causes.At present,prethrombotic state(PTS)has attracted more attention in the research of RAS.PTS can induce microthrombosis of placenta,villus infarct and fibroid necrosis of decidua vessels,which can lead to ischemia and hypoxia of embryonic tissues.In clinic,western medicine treatment is mainly about immunotherapy and anticoagulant therapy,but the influence of the above treatments on pregnancy outcome is still uncertain.The long-term use of low molecular weight heparin and anti-platelet drugs can induce side effects,such as thrombocytopenia,osteoporosis,bleeding tendency,allergy and vertebral fracture,and it also can increase the risk of placental abruption and premature delivery.Therefore,it is urgent to explore new treatment methods to make up for the current treatment plan.TCM treats RAS in terms of Kidney-deficiency and blood stasis,the therapy of tonifying Kidney and activating blood to remove stasis was applied according to the stage differentiation before and after pregnancy.The therapy can achieve remarkable effect when combined with western medication,which is worthy of clinical promotion.
作者
平昀鹭
赵小萱
冯晓玲
邹康西
PING Yunlu;ZHAO Xiaoxuan;FENG Xiaoling;ZOU Kangxi(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中医药学报》
CAS
2020年第10期64-68,共5页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金资助项目(81973894)
黑龙江中医药大学“优秀创新人才支持计划”项目(2018RCL12)。
关键词
血栓前状态
复发性流产
肾虚血瘀
中医药治疗
分期论治
Prethrombotic state
Recurrent spontaneous abortion
Kidney-deficiency and blood stasis
TCM treatment
Treatment by stage
