摘要
目的探讨125I粒子植入治疗骨转移瘤患者的有效性和安全性。方法将骨转移瘤患者54例分为两组,其中行125I粒子植入的30例患者为治疗组,植入粒子总数1581粒,平均每例植入(52±6)粒,另24例患者行药物治疗为对照组,比较两组的疼痛治疗有效率(NRS评分)、功能状态改善有效率(KPS评分)、以及病灶治疗疗效的差异,比较两组治疗前后的血清碱性磷酸酶(ALP)变化,不良反应和并发症的发生情况。结果治疗组的功能状态改善率为60%,高于对照组的29.2%;治疗组的镇痛显效率为36.2%,高于对照组的4.2%;病灶治疗的临床有效率为93.3%,高于对照组的8.3%,差异均有统计学意义(均P<0.05)。治疗组治疗后血清ALP水平降低,差异有统计学意义(P<0.05)。无严重不良反应和125I粒子植入能有效缓解骨转移瘤引起的疼痛,提高生活质量,是一种安全、有效的治疗方法。
Objective To evaluate the effectiveness and safety of 125I particles implantation in treating patients with bone metastases.Methods A total of 54 patients with bone metastases were divided into study group(n=30)and control group(n=24).Implantation of 125I particles was adopted in the patients of the study group,the total number of seeds implanted was 1581,with an average of(52±6)particles per patient.For the patients of the control group,only medication was adopted.The effective rates of pain relief based on numerical rating scale(NRS)score as well as functional improvement based on Karnofsky performance status(KPS)score,and the curative effect of lesions were compared between the two groups.The postoperative changes in serum alkaline phosphatase(ALP)levels,the untoward effect and complications were also compared between the two groups.Results The improvement rate of patients’functional state in the study group was 60%,which was higher than 29.2%in the control group.The apparent analgesic effect in the study group was 36.2%,which was higher than 4.2%in the control group.The clinical curative effect of lesions in the study group was 93.3%,which was higher than 8.3%in the control group.The differences in all the above items between the two groups were statistically significant(P<0.05).No serious adverse reactions or complications occurred.Conclusion For relieving pain caused by bone metastases,implantation of125 I particles is a safe and effective therapeutic method and this therapy can reliably improve the quality of life.
作者
费伦
郭金友
郑家平
梅伟东
韩瑞雪
沈剑英
FEI Lun;GUO Jinyou;ZHENG Jiaping;MEI Weidong;HAN Ruixue;SHEN Jianying(Department of Oncology,Yuhuan Municipal Second People’s Hospital,Yuhuan,Zhejiang Province 317605,China)
出处
《介入放射学杂志》
CSCD
北大核心
2020年第9期930-933,共4页
Journal of Interventional Radiology
基金
浙江省医药卫生一般研究计划项目(2016KYA043,2013KYB041)。
关键词
125I放射性粒子
骨转移瘤
癌痛
KPS
NRS
125I radioactive seed
bone metastasis
cancer pain
Karnofsky performance status
numerical rating scale
