摘要
目的:探讨柴胡承气汤联合乌司他丁对重症急性胰腺炎患者T淋巴细胞亚群和炎症因子的影响。方法:将重症急性胰腺炎患者80例按入院顺序经随机数字表法分为两组各40例,对照组予乌司他丁治疗,研究组在对照组基础上联合柴胡承气汤治疗,对比两组患者临床症状消失时间、T淋巴细胞亚群和炎症因子水平。结果:研究组患者腹痛消失、体温恢复、肛门排便及腹胀消失时间均短于对照组(P<0.05);两组患者肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、高敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)、白细胞介素6(interleukin-6,IL-6)、白细胞介素8(interleukin-8,IL-8)等水平均较治疗前降低,研究组降低更显著(P<0.05);治疗后两组患者CD4+、CD4+/CD8+水平均较治疗前升高,CD8+较治疗前降低,且研究组变化更显著(P<0.05)。结论:柴胡承气汤联合乌司他丁可有效改善重症急性胰腺炎患者临床症状,调节其T淋巴细胞亚群和炎症因子水平。
Objective: To explore the effects of Chaihu Chengqi Tang and ulinastatin on T lymphocyte subsets and inflammatory factors in SAP patients. Methods: Eighty SAP patients were allocated to two groups according to admission order via random number table method, the control group were treated by ulinastatin, the study group took Chaihu Chengqi Tang based on ulinastatin, to compare the disappearing time of clinical symptoms, T lymphocyte subsets and inflammatory factors between both groups. Results: The study group was shorter than the control group in the disappearing time of abdominal pain, the recovery time of body temperature and anal defecation, and disappearing time of abdominal distension(P <0.05);the levels of TNF-α, hs-CRP, IL-6, IL-8 and others in both groups were lower than these before treating, and the decrease of the study group was more notable(P<0.05);after treating, the levels of CD4^+ and CD4^+/CD8^+ of boh groups rose compared with these before treating, CD8^+ reduced than before treating, and the changes of the study group were more remarkable(P<0.05). Conclusion: Chaihu Chengqi Tang and ulinastatin could effectively improve clinical symptoms of SAP patients, regulate the levels of T lymphocyte subsets and inflammatory factors.
作者
黄丹虹
王国平
HUANG Danhong;WANG Guoping(Department of Critical Care Medicine,Shenzhou Hospital,Guangzhou University,Shenzhen 518000,China)
出处
《西部中医药》
2020年第9期88-91,共4页
Western Journal of Traditional Chinese Medicine
基金
广东省中医药局项目(2018KT1184)。
