摘要
目的探讨角膜塑形镜联合小牛血去蛋白提取物滴眼液矫正青少年近视的效果。方法选择2018年7月至2019年7月平利县医院和慧仁眼耳鼻喉医院接受治疗的70例(140眼)青少年近视患者为研究对象,按照随机数字表法将其均分为试验组与对照组(每组各35例70眼),对照组接受常规角膜塑形镜治疗,试验组在对照组基础上加用小牛血去蛋白提取物滴眼液。比较两组患者戴镜前、戴镜1周及戴镜1个月时的角膜曲率、角膜表面规则指数(SRI)、泪膜脂质层厚度(LIT)、泪膜破裂时间(BUT)、眼表疾病指数(OSDI)评分,以及戴镜1周及戴镜1个月时角膜上皮着染发生率。结果两组患者戴镜1周及1个月时角膜曲率均较戴镜前下降,SRI均较戴镜前升高(P<0.05),但组间比较差异均无统计学意义(P>0.05)。两组患者戴镜1周及1个月时BUT及LIT均较戴镜前下降(P<0.05),且试验组均高于对照组(P<0.05)。两组患者戴镜1周及1个月时OSDI评分均较戴镜前升高(P<0.05),且试验组均低于对照组(P<0.05)。试验组患者戴镜1周及1个月时角膜上皮着染率均低于对照组(P<0.05)。结论角膜塑形镜对青少年近视具有较好的矫正效果,联合应用小牛血去蛋白提取物滴眼液能保护和修复角膜上皮。
Objective To investigate the effects of orthokeratology combined with calf blood deproteinized eye drops in correcting myopia in adolescents.Methods From July 2018 to July 2019,70 adolescent myopia patients(140 eyes)who received treatment in the Pingli County Hospital and Huiren Eye,Ear,Nose and Throat Hospital were selected as the research objects,and they were divided into the experimental group and the control group according to the random number table method,35 cases in each group with 70 eyes.Patients in the control group received conventional orthokeratology treatment,and patients in the experimental group were treated with calf blood deproteinized eye drops on the basis of the control group.The corneal curvature,corneal surface regular index(SRI),tear film lipid layer thickness(LIT),tear film rupture time(BUT),ocular surface disease index(OSDI)score before wearing glasses,1 week and 1 month after wearing glasses were compared between the two groups.Results The corneal curvature of the two groups of patients after wearing the glasses for 1 week and 1 month was lower than before wearing the glasses,and the SRI was higher than before wearing the glasses(P<0.05),but there was no significant difference between the groups(P>0.05).The BUT and LIT of the two groups were lower than before wearing the glasses for 1 week and 1 month(P<0.05),and the experimental group was higher than the control group(P<0.05).The OSDI score of the two groups of patients wearing glasses for 1 week and 1 month was higher than that of wearing glasses(P<0.05),and the experimental group was lower than the control group(P<0.05).The corneal epithelial staining rate of patients in the experimental group was lower than that in the control group when they wore the glasses for 1 week and 1 month(P<0.05).Conclusion Orthokeratology has a good corrective effect on juvenile myopia.Combined application of deproteinized calf blood eye drops can protect and repair corneal epithelium.
作者
刘梅香
韩曙生
LIU Meixiang;HAN Shusheng(Department of Facial Features,Pingli County Hospital,Ankang,Shaanxi 725500,China;Department of Ophthalmology,Huiren Eye,Ear,Nose and Throat Hospital Weinan,Shaanxi 714000,China)
出处
《检验医学与临床》
CAS
2020年第19期2814-2817,共4页
Laboratory Medicine and Clinic
