摘要
目的探讨氨甲环酸联合欣母沛、卡贝缩宫素治疗前置胎盘产后出血的临床效果。方法抽取2017年7月至2020年1月济源市人民医院收治的75例前置胎盘产后出血患者,随机分为常规组(37例)与研究组(38例)。常规组采用欣母沛、卡贝缩宫素治疗,研究组采用氨甲环酸联合欣母沛、卡贝缩宫素治疗。比较两组宫缩持续时间、恶露持续时间、阴道出血总量、纱布填塞率、转手术率及子宫切除率;比较两组凝血功能变化情况及不良反应发生情况。结果研究组宫缩持续时间[(3.28±0.54)h]长于常规组[(1.96±0.32)h],恶露持续时间[(6.15±1.20)d]短于常规组[(9.52±1.44)d],阴道出血总量[(698.75±120.20)ml]少于常规组[(805.97±145.86)ml],纱布填塞率(15.79%,6/38)和转手术率(2.63%,1/38)低于常规组(37.84%,14/37;21.62%,8/37),差异均有统计学意义(P均<0.05)。两组子宫切除率比较差异未见统计学意义(P>0.05)。产后48 h,两组凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)均较分娩前缩短,纤维蛋白原(FIB)均较分娩前升高,且研究组PT、APTT均短于常规组[(11.60±1.71)s比(14.25±1.82)s;(24.60±4.71)s比(32.25±5.82)s],FIB高于常规组[(5.61±0.89)g/L比(4.52±0.77)g/L],差异均有统计学意义(P均<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论氨甲环酸联合欣母沛、卡贝缩宫素治疗前置胎盘产后出血可促进康复,减少纱布填塞和手术,调节凝血功能,且安全性好。
Objective To investigate the effects of tranexamic acid combined with xinmupei and carbetoxine on postpartum hemorrhage of placenta previa(PPH).Methods A total of 75 patients with PPH in Jiyuan People’s Hospital from July 2017 to January 2020 were selected and randomly divided into routine group(37 cases)and study group(38 cases).The routine group was treated with xinmupei and carbetaxel,while the study group was treated with tranexamic acid combined with xinmupei and carbetoxine.The duration of uterine contraction,duration of lochia,total amount of vaginal bleeding,filling rates of gauze,conversion rate and hysterectomy rate were compared,and the coagulation function and adverse reactions were compared between the two groups.Results The duration of uterine contraction in the study group was(3.28±0.54)h,longer than the(1.96±0.32)h in the routine group(P<0.05);the duration of lochia in the study group was(6.15±1.20)d,shorter than the(9.52±1.44)d in the routine group(P<0.05);the total amount of vaginal bleeding in the study group was(698.75±120.20)ml,smaller than the(805.97±145.86)ml in the routine group(P<0.05);the filling rate of gauze(15.79%,6/38)and conversion rate(2.63%,1/38)in the study group were lower than the 37.84%(14/37)and 21.62%(8/37)in the routine group(all P<0.05).There was no significant difference in hysterectomy rates between the two groups(P>0.05).At 48 h postpartum,prothrombin time(PT)and activated partial thromboplastin time(APTT)in both groups were shorter than those before delivery,and fibrinogen(FIB)was higher than that before delivery,and the PT and APTT in the study group were(11.60±1.71)s and(24.60±4.71)s,respectively,shorter than the(14.25±1.82)s and(32.25±5.82)s in the routine group(P<0.05);the FIB in the study group was(5.61±0.89)g/L,higher than the(4.52±0.77)g/L in the routine group(all P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusions The treatment of postpartum hemorrhage of placenta previa with tranexamic acid combined with xinmupei and carbetoxine can promote recovery,reduce gauze packing and operation,regulate coagulation function,with high safety.
作者
李婷婷
党利梅
范静
Li Tingting;Dang Limei;Fan Jing(Department of Obstetrics,Jiyuan People’s Hospital,Jiyuan 459000,China)
出处
《中国实用医刊》
2020年第17期98-101,共4页
Chinese Journal of Practical Medicine
关键词
前置胎盘
产后出血
氨甲环酸
欣母沛
卡贝缩宫素
Placenta previa
Postpartum hemorrhage
Tranexamic acid
Simupine
Carbetoxine
