摘要
目的 探讨中药雾化吸入对防治冠状动脉旁路移植术(CABG)老年患者并发肺部感染的作用.方法 选择2015年1月至2017年1月山西中医药大学附属医院和太原市人民医院收治的确诊为冠状动脉粥样硬化性心脏病(冠心病)行CABG后肺部感染患者40例作为研究对象,将患者按雾化吸入药物不同分为中药雾化组(将丹参注射液4mL和鱼腥草注射液4mL溶入12mL生理盐水中雾化吸入)和西药雾化组(将沐舒坦注射液2mL加入18mL生理盐水中雾化吸入),每组20例.征得研究合作单位的同意,研究人员与重症监护病房(ICU)主班护士共同协作,在拔除气管插管后的第1次雾化吸入后完成资料收集.观察并分析两组患者术后排痰效果、动脉血气等围术期指标.结果 两组雾化吸入前后排痰量比较差异均无统计学意义(均P>0.05).中药雾化组雾化吸入后痰鸣音积分较雾化吸入前明显降低,西药雾化组雾化吸入前后痰鸣音积分比较差异无统计学意义(P>0.05),故中药雾化组雾化吸入后痰鸣音积分明显低于西药雾化组(分:0.70±0.47比0.95±0.60,P<0.05).两组雾化吸入后动脉血二氧化碳分压(PaCO2)均较雾化吸入前有所升高〔中药雾化组(mmHg,1mmHg≈0.133kPa):34.70±2.81比32.50±4.15,西药雾化组(mmHg):34.75±2.29比33.17±5.88〕,但两组雾化吸入后PaCO2比较差异无统计学意义(P>0.05);两组雾化吸入后动脉血氧分压(PaO2)均较雾化吸入前明显升高,且中药雾化组雾化吸入后PaO2明显高于西药雾化组(mmHg:79.58±5.40比76.80±4.77,P<0.05).结论 丹参注射液和鱼腥草注射液合用进行雾化吸入效果优于单用沐舒坦注射液.
Objective To explore the efeet of traditional Chinese medicine(TCM)inhalation on prevention and treatment of pulmonary ifction in elderly patients undergoing coronary artery bhypass gating(CABG)、Methods The 40 patients with confirmed diagnosis of artherosclerotic coronary heart disease(coronary heart disease)and complicated with pulmonary infection after undergoing CABG adnmitted to Afiliated Hospital of Shanxi University of Traditional Chinese Medieine(TCM)and Taiyuan People's Hospital from January 2015 to January 2017 were selected as research objects,and according to difference in aerosol inhalation drugs,they were divided into a TCM inhalation group(4 mL of Danshen Injection and 4 mL of Houttuynia Injection added into 12 mL normal saline for inhalation)and a Western medieine(WM)inhalation group(2 mL of Mucosolvan Injeetion added into 18 mL of normal saline for inhalation).With the consent of research cooperation unit,the researchers and Intensive Care Unit(ICU)nurses worked together to complete the data collection from the first time inhalation after the removal of tracheal intubation.The postoperative expectoration effect(sputum volume)and perioperative indexes of arterial blood gas analysis in the thwo groups were observed and analyzed.Results There were no statistical significant differences in sputum volume between the two groups before and after inhalation(both P>0.05).In TCM inhalation group,the phlegm sound score after inhalation was significantly lower than that before inhalation,while in WM inhalation group,there was no significant difference in the phlegm sound score before and afier inhalation(P>0.05),therefore,the phlegm sound scores in TCM inhalation group after inhalation was significantly lower than that in WM inhalation group(points:0.70+0.47 vs.0.95±0.60,P<0.05).The partial pressure of arterial blood carbon dioxide(PaCO2)after inhalation in two groups were higher than those hefore inhalation[TCM inhalation group(mmHg,1 mmHg≈0.133 kPa):34.70±2.81 v8.32.5+4.15,WM inhalation group(mmHg):34.75±2.29 vs.33.17±5.88];however,there was no statistical significant difference in PaCO2 between two groups after inhalation(P>0.05);the levels of arterial blood parial pressure of oxygen(PaO2)were inereased signifcanly after inhalation in both groups,and the level of PaOz after inhalation in TCM inhalation group was obviously higher than that in WM inhalation group(mmHg:79.58±5.40 vs.76.80±4.77,P<0.05),Conclusion The therapeutic effect of aerosol inhalation with TCM combination of Danshen and Houttuynia Injection prepared solution is superior to that of using WM ambroxol injection prepared agent alone.
作者
王彩星
王美瑛
吴超
张琼
Wang Caixing;Wang Meiying;Wu Chao;Zhang Qiong(Shanxi University of Traditional Chinese Medicine,Jinzhong 030619,Shanxi,China;Taiyuan People's Hospital,Taiyuan 030001,Shanxi,China;The Hospital of Shanxi University of Chinese Medicine,Taiyuan 030024,Shanxi,China)
出处
《中国中西医结合急救杂志》
CAS
CSCD
北大核心
2020年第5期566-568,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
山西省科技攻关计划(20150313005-6)。
关键词
冠状动脉旁路移植术
中药雾化吸入
围术期干预
肺部感染
Coronary artery by pass grafting
Traditional Chinese medicine aerosol inhalation
Perioperative intervention
Pulmonary infection
