摘要
氧化苦参碱具有广泛的生物活性,如保护心、肝、肺、肾、脑、血管作用,对心脏有正性肌力、负性频率、抗心律失常作用,还有升高白细胞,平喘,抗溃疡,抗纤维化以及镇静、催眠、镇痛等中枢神经药理作用,也具有抗肿瘤、免疫调节、抗菌、抗病毒、抗炎等药理作用。氧化苦参碱是一种亲水性很强的弱碱性药物,易被代谢成苦参碱,尤其在口服给药时可被看做为苦参碱的前药。通过综述氧化苦参碱药动学参数、体内过程,总结氧化苦参碱的药动学研究进展,为合理用药提供参考。
Oxymatrine has a widespread bioactivities,including protection of heart,liver,lung,kidney,brain and blood vessel,and the effects of positive inotropism,negative chronotropism and antiarrhythmia on heart,and promoting leukocytes,antiasthma,antiulcer,anti-fibrogenesis,and central suppression of sedation,hypnogenesis,analgesia,and antitumor,immunoregulation,antibacteria,anti-virus and anti-inflammation.Oxymatrine is a strong hydrophilic and weakly alkaline drug.Oxymatrine is easily transformed into matrine,especially when it is given orally.Oxymatrine can be regarded as a prodrug of matrine.The pharmacokinetic parameters and process in body of oxymatrine are reviewed,and its research advances on pharmacokinetics is summarized,which provides a reference for rational utilization of oxymatrine.
作者
张明发
沈雅琴
ZHANG Mingfa;SHEN Yaqin(Shanghai Meiyou Pharmaceutical Co.Ltd.,Shanghai 201204,China)
出处
《药物评价研究》
CAS
2020年第9期1903-1911,共9页
Drug Evaluation Research
关键词
氧化苦参碱
苦参碱
药动学
药理作用
合理用药
oxymatrine
matrine
pharmacokinetics
pharmacologic effect
rational use of drug
