摘要
目的探讨妊娠中期不同剂量碳酸钙联合维生素D3对妊娠期糖尿病(GDM)患者胰岛功能及妊娠结局的影响。方法选取医院门诊2016年6月至2018年6月接诊的孕妇100例,按是否有GDM分为对照组(健康孕妇)和观察组(GDM孕妇),各50例。对照组与观察组患者均于妊娠24周起口服碳酸钙D3片,每次分别1片、2片,每日1次,均持续4周。结果治疗后,观察组患者的胰岛素抵抗指数及24 h尿钙均显著低于对照组,胰岛素分泌指数显著高于对照组(P <0.05);两组孕妇的空腹血糖、空腹胰岛素、餐后2 h血糖及血磷、血钙水平均无显著差异(P> 0.05);观察组母婴并发症发生率显著低于对照组(P <0.05);两组孕妇不良反应发生率无显著差异(P> 0.05)。结论 GDM患者孕中期以碳酸钙联合较高剂量维生素D3可有效减少骨钙丢失,降低胰岛素敏感性,改善妊娠结局。
Objective To investigate the effect of different doses of calcium carbonate combined with vitamin D3 on pancreatic islet function and pregnancy outcomes in patients with gestational diabetes mellitus( GDM) in the second trimester of pregnancy.Methods A total of 100 pregnant women admitted to the outpatient department of the hospital from June 2016 to June 2018 were selected and randomly divided into the control group( healthy pregnant women) and observation group( patients with GDM),50 cases in each group.Both groups took calcium carbonate D3 daily from the 24th week of gestation,one tablet for each case in the control group and two in the observation group,once a day for a continuous four weeks.Results After treatment,the observation group’s insulin resistance index and 24 h urine calcium were significantly lower than those of the control group,and the insulin secretion index was significantly higher than that of the control group( P < 0.05);the levels of fasting blood glucose,fasting insulin,2 h postprandial glucose,blood phosphorus,and blood calcium of the two groups showed no significant difference( P > 0.05);the incidence of maternal and infant complications in the observation group was significantly lower than that in the control group( P < 0.05).There was no significant difference in adverse reactions between the two groups( P > 0.05).Conclusion Calcium carbonate combined with high dose of vitamin D3 for patients with GDM in the second trimester of pregnancy can effectively reduce bone calcium loss and insulin sensitivity,thus improving maternal and fetal pregnancy outcomes.
作者
孔祥天
徐爱萍
吴佳聪
成晓燕
曹娴
蒋鸿儒
倪钰飞
KONG Xiangtian;XU Aiping;WU Jiacong;CHENG Xiaoyan;CAO Xian;JIANG Hongru;NI Yufei(Nantong Maternal and Child Health Care Center,Nantong,Jiangsu,China 226018)
出处
《中国药业》
CAS
2020年第19期91-93,共3页
China Pharmaceuticals
基金
江苏省妇幼保健协会科研项目[FYX201607]。
关键词
妊娠中期
碳酸钙
剂量
妊娠期糖尿病
胰岛功能
妊娠结局
the second trimester of pregnancy
calcium carbonate
dose
gestational diabetes mellitus
islet function
pregnancy outcomes
