摘要
目的探讨血清N端B型钠尿肽原(NT-proBNP)和心肌肌钙蛋白Ⅰ(cTnⅠ)联合检测在慢性心力衰竭(CHF)诊断中的临床价值。方法选取105例CHF患者设为CHF组,根据美国纽约心脏病学会心力衰竭程度分级(NYHA分级)标准将其分为:Ⅰ级组22例,Ⅱ级组32例,Ⅲ级组30例,Ⅳ级组21例。另选取80例健康体检者作为健康对照组。所有研究对象均进行血清NT-proBNP、cTnⅠ水平检测,超声心电图左室射血分数(LVEF)及左室舒张末内径(LVEDD)检测。结果CHF组患者与对照组比较,NT-proBNP、cTnⅠ浓度显著升高(P<0.05),LVEF水平显著降低(P<0.05),LVEDD水平显著升高(P<0.05)。CHF患者NT-proBNP、cTnⅠ联合检测敏感度(96.1%)及特异度(92.5%)高于单项检测。不同NYHA分级CHF患者治疗后与治疗前比较,NT-proBNP、cTnⅠ水平均显著降低(P<0.05)。结论CHF患者血清NT-proBNP、cTnⅠ水平随着CHF严重程度增加而升高,联合检测NT-proBNP、cTnⅠ,可为CHF早期诊断提供诊疗依据,指导临床对CHF患者及时干预。
Objective To investigate the clinical value of combined detection of serum N-terminal B-type natriuretic peptide(NT-proBNP)and cardiac troponinⅠ(cTnⅠ)in the diagnosis of chronic heart failure(CHF).Methods A total of 105 patients with CHF were enrolled in the CHF group.According to the New York Heart Association Heart Failure Rating(NYHA classification)criteria,they were divided into GroupⅠ(n=22),GroupⅡ(n=32),GroupⅢ(n=30),and GroupⅣ(n=21).Another 80 healthy subjects were selected as healthy controls.All patients received tests of serum NT-proBNP,cTnⅠlevels,echocardiographic left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDD).Results Compared with the control group,the concentrations of NT-proBNP and cTnⅠwere significantly increased in the Group CHF(P<0.05),the LVEF level was significantly reduced(P<0.05),and the LVEDD level was significantly increased(P<0.05).Compared with the control group,NT-proBNP and cTnⅠconcentrations were significantly increased in the Group CHF(P<0.05),LVEF levels were significantly lower(P<0.05),and LVEDD levels were significantly higher(P<0.05).The sensitivity(96.1%)and specificity(92.5%)of combined detection of NT-proBNP and cTnⅠin CHF patients were significantly higher than those in single subjects.NT-proBNP and cTnⅠlevels were significantly lower after treatment in patients with different NYHA grade CHF than before treatment(P<0.05).Conclusion The levels of serum NT-proBNP and cTnⅠin CHF patients increase with the severity of CHF.Combined detection of NT-proBNP and cTnⅠcan provide a basis for early diagnosis and treatment of CHF,and guide the intervention of CHF.
作者
曹倩
钱磊
韩磊
段倩倩
晁艳艳
CAO Qian;QIAN Lei;HAN Lei;DUAN Qian-qian;CHAO Yan-yan(Clinical Laboratory,the 83rd Army Hospital of the Chinese People's Liberation Army,Xinxiang 453000,Henan,China;不详)
出处
《广东医学》
CAS
2020年第18期1896-1899,共4页
Guangdong Medical Journal
关键词
N端B型钠尿肽原
心肌肌钙蛋白Ⅰ
慢性心力衰竭
联合检测
不同分级
N-terminal pro-B-type natriuretic peptide
cardiac troponinⅠ
chronic heart failure
combined detection
different grading
