摘要
动脉粥样硬化是一种慢性炎症性疾病,涉及内皮细胞凋亡、血管平滑肌细胞增殖和泡沫细胞形成等。信号转导和转录激活因子3(STAT3)参与细胞生长、凋亡等多种生命活动,在动脉粥样硬化中发挥着重要作用。本文对目前STAT3在动脉粥样硬化发生发展中的作用进行综述。
Atherosclerosis is a chronic inflammatory disease involving endothelial cells apoptosis,vascular smooth muscle cells proliferation and foam cells formation.Signal transduction and activator of transcription 3(STAT3)participates in many life activities such as cell growth and apoptosis,and plays an important role in atherosclerosis.This article reviews the role of STAT3 in the development of atherosclerosis.
作者
许爽
倪焕尔
陈航炜
戴秋艳
Shuang XU;Huan-Er NI;Hang-Wei CHEN;Qiu-Yan DAI(Department of Cardiology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)
出处
《医学新知》
CAS
2020年第5期383-388,共6页
New Medicine
基金
国家自然科学基金面上项目(81370415,81670399)。
