摘要
新型冠状病毒(SARS-CoV-2)核酸检测是金标准,抗原抗体检测是核酸检测的重要辅助手段。核酸与抗原检测是患者早期感染的直接证据,但不能提示患者是否既往感染。抗体检测是患者感染的间接证据,IgM阳性提示急性感染,IgG阳性提示病情中后期或既往感染。同时,抗体检测可作为评价疫苗与抗体治疗药物临床效果的重要指标。虽然抗原检测可作为早期诊断的直接证据,但灵敏度不高,尚未获得认可。因此,核酸、抗原和抗体联合检测能提高临床检测的敏感度和特异度,为复工、复产提供重要依据。
Novel coronavirus(SARS-CoV-2)nucleic acid detection is a gold standard.Antigen and antibody tests can be used as an aid for nucleic acid assay.Both nucleic acid and antigen detections are known as a direct evidence for the early infection,but they could not identify patients whether or not have a previous infection.Antibody testing is indirect evidence of patient infection.Positive IgM indicates acute infection,and IgG positive indicates previous infection.Simultaneously,阿ntibody testing can be used as an important indicator to evaluate the clinical effects of vaccines and antibody therapeutics.Although antigen detection can be used as direct evidence for early diagnosis,the sensitivity is not high and has not yet been recognized.Therefore,the panel testing for nucleic acid/antigen/antibody can improve the sensitivity and specificity of clinical detection and provide an important basis for resuming work and resuming production.
作者
张园
周泽奇
王志贤
粟艳
肖盟
徐英春
王贺
ZHANG Yuan;ZHOU Ze-qi;WANG Zhi-xian;SU Yan;XIAO Meng;XU Ying-chun;WANG He(Dynamiker Sub-Center for Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Disease,Tianjin 300467,China;Department of Laboratory Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases(BZ0447),Beijing 100730,China)
出处
《现代检验医学杂志》
CAS
2020年第5期99-102,109,共5页
Journal of Modern Laboratory Medicine
基金
国家科技重大专项“艾滋病和病毒性肝炎等重大传染病防治”课题(编号2020ZX101015)
天津市重大科技专项“新型冠状病毒感染应急防治”课题(编号20ZXGBSY00040)
天津市科技计划“侵袭性真菌病新型体外诊断试剂及POCT自动化检验分析仪的研发”课题(编号:2020ZX101015)
中国博士后科学基金“基于假病毒技术的新型冠状病毒中和抗体检测模型的建立及临床应用价值”课题(编号2020T1300011ZX)。
