摘要
干眼在全球的患病率日益增高,其发病机制尚不明确。研究表明炎症和氧化应激是其主要的致病机制。体内和体外的多种刺激因素都会激活氧化应激反应,活性氧水平与抗氧化酶作用的失衡会激活炎症反应,造成眼表组织损伤,最终导致干眼。本文综述炎症和氧化应激在干眼发病中的重要作用及抗炎治疗。
The incidence of dry eye is increasing worldwidely,and its pathogenesis is unclear yet.Studies have shown that oxidative stress is an important factor leading to many acute and chronic diseases and aging.The ocular surface contribute the first line of defense to the eye from oxidative stress,which is caused by the imbalance between the production of reactive oxygen species and anti-oxidative system.This review focuses on the evaluation of the influence of inflammation and oxidative stress emphasizing their relation with the pathogenesis of dry eye and anti-inflammation strategy.
作者
刘慧
赵少贞
Hui Liu;Shao-Zhen Zhao(Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, College of Optometry and Ophthalmology, Tianjin Medical University, Tianjin 300384, China)
出处
《国际眼科杂志》
CAS
北大核心
2020年第11期1920-1923,共4页
International Eye Science
基金
天津市教委科研计划项目(No.2018KJ054)。
关键词
干眼
炎症
氧化应激
dry eye
inflammation
oxidative stress
