摘要
目的探讨紫杉醇脂质体联合卡铂治疗卵巢癌的效果。方法选择2017年1月~2019年6月我院进行治疗的60例卵巢癌患者为研究对象,按照随机数字表法分为对照组与观察组,每组30例。对照组接受紫杉醇联合卡铂治疗,观察组接受紫杉醇脂质体联合卡铂治疗。比较两组患者的短期预后、服药期间毒副作用以及疗程结束时生存质量。结果两组疗程结束时的治疗总有效率比较,差异无统计学意义(P>0.05);观察组服药期间的恶心呕吐、乏力、肌肉疼痛、皮疹发生率均低于对照组,差异有统计学意义(P<0.05);观察组疗程结束时的躯体功能评分、角色功能评分、认知功能评分、情绪功能评分、社会功能评分均高于对照组,差异有统计学意义(P<0.05)。结论紫杉醇脂质体与紫杉醇联合卡铂治疗卵巢癌的效果相似,但紫杉醇脂质体安全性更好,患者生存质量更高。
Objective To investigate the effect of Paclitaxel Liposome combined with Carboplatin in the treatment of ovarian cancer.Methods A total of 60 cases of ovarian cancer treated in our hospital from January 2017 to June 2019 were selected as the resrarch objects,and they were divided into the control group and the observation group according to the random number table method,30 cases in each group.The control group received Paclitaxel combined with Carboplatin treatment,the observation group received Paclitaxel Liposome combined with Carboplatin treatment.The short-term prognosis,side effects and quality of life at the end of treatment were compared between the two groups.Results There was no significant difference in the total effective rate between the two groups at the end of treatment(P>0.05).The incidence of nausea,vomiting,fatigue,muscle pain and rash in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The scores of body function,role function,cognitive function,emotional function and social function in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion The efficacy of Paclitaxel Liposome is similar to that of Paclitaxel combined with Carboplatin in the treatment of ovarian cancer,but Paclitaxel Liposome has better safety and higher quality of life.
作者
廖振蓉
申昌梅
余瑛
LIAO Zhen-rong;SHEN Chang-mei;YU Ying(Department of Gynecologic Oncology,Ganzhou Tumor Hospital in Jiangxi Province,Ganzhou341000,China)
出处
《中国当代医药》
2020年第29期91-93,共3页
China Modern Medicine
关键词
卵巢癌
紫杉醇脂质体
卡铂
安全性
生存质量
Ovarian cancer
Paclitaxel Liposome
Carboplatin
Safety
Quality of life
