摘要
研究一种清洁、温和、高效的氟唑菌酰胺合成方法。创造性地以1,2,3-三氯苯为起始原料,经氟化、溴化、格氏、偶联、加氢还原、缩合6步反应合成了氟唑菌酰胺。总收率50%以上,含量99%以上,并通过液相色谱、核磁氢谱等分析手段确认了关键中间体及氟唑菌酰胺结构。该工艺路线清洁、高效、可行,具有较好的工业化应用前景。
This paper aims to develop a clean,mild and efficient method for the synthesis of fluxapyroxad.Fluxapyroxad was synthesized from 1,2,3-trichlorobenzene by six steps including fluorination,bromination,Grignard,coupling,hydrogenation reduction and condensation.The total yield was more than 50%and the content was more than 99%.The structure of key intermediate and fluxapyroxad were confirmed by HPLC and 1H NMR.The process is more clean,efficient and feasible,and has a good prospect of industrial application.
作者
尹凯
顾旻旻
柴华强
于江
YIN Kai;GU Minmin;CHAI Huaqiang;YU Jiang(Zhejiang Nanjiao Chemicals Co.,Ltd.,Shaoxing 312369,Zhejiang,China)
出处
《世界农药》
CAS
2020年第10期41-45,共5页
World Pesticide
关键词
氟唑菌酰胺
合成
新工艺
fluxapyroxad
synthesis
new process
