摘要
目的:检测乙型肝炎肝硬化患者血清可溶性细胞间黏附分子-1(s ICAM-1)、白细胞介素-6(IL-6)、白细胞介素-18(IL-18)及肿瘤坏死因子-α(TNF-α)水平,并探讨其临床意义。方法:选取2017年1月至2019年6月我院收治的乙型肝炎肝硬化患者82例作为研究组,同期健康体检者80例作为对照组。比较研究组和对照组及不同Child-Pugh分级乙型肝炎肝硬化患者血清s ICAM-1、IL-6、IL-18、TNF-α、肝功能指标血浆谷丙氨酸氨基转移酶(ALT)、白蛋白(ALB)水平,并分析各指标之间的相关性。结果:研究组血清s ICAM-1、IL-6、IL-18、TNF-α和血浆ALT水平分别为(820.78±85.73)ng/mL、(41.71±13.24)ng/mL、(119.85±45.56)pg/mL、(52.23±22.24)ng/L、(155.20±56.27)U/L,显著高于对照组的(175.51±41.82)ng/mL、(6.67±2.23)ng/mL、(68.71±23.24)pg/mL、(5.65±1.28)ng/L、(15.65±5.23)U/L(P<0.05),血浆ALB水平显著低于对照组[(27.69±4.32)g/L vs(45.16±5.65)g/L](P<0.05)。随Child-Pugh分级的升高,乙型肝炎肝硬化患者血清s ICAM-1、IL-6、IL-18、TNF-α和血浆ALT水平逐渐升高,血浆ALB水平逐渐降低(P<0.05)。乙型肝炎肝硬化患者血清s ICAM-1、IL-6、IL-18及TNF-α水平与血浆ALT水平呈正相关(P均<0.05),与血浆ALB水平呈负相关(P均<0.05),乙型肝炎肝硬化患者血清s ICAM-1与IL-6、IL-18及TNF-α呈正相关(P均<0.05)。结论:乙型肝炎肝硬化患者血清s ICAM-1、IL-6、IL-18、TNF-α水平异常升高,与Child-Pugh分级和肝功能有关,检测血清s ICAM-1、IL-6、IL-18、TNF-α可能为乙型肝炎肝硬化的诊断和病情严重程度的判断提供依据。
Objective: To measured the levels of serum soluble intercellular adhesion molecule-1(s ICAM-1), interleukin-6(IL-6),interleukin-18(IL-18) and tumor necrosis factor-α(TNF-α) in patients with hepatitis B and cirrhosis, and to explore their clinical significance. Methods: 82 patients with hepatitis B and cirrhosis who were admitted to our hospital from January 2017 to June 2019 were selected as the study group, and 80 healthy people in the same period as the control group. The levels of serum s ICAM-1, IL-6, IL-18,TNF-α, ALT and ALB were compared between the study group and the control group, as well as the patients with different Child-Pugh grades of hepatitis B and cirrhosis, and the correlation between the indexes was analyzed. Results: The levels of s ICAM-1, IL-6, IL-18,TNF-α and plasma ALT in the study group were(820.78±85.73)ng/mL,(41.71±13.24)ng/mL,(119.85±45.56)pg/mL,(52.23±22.24)ng/L,(155.20±56.27)U/L, which were significantly higher than(175.51±41.82)ng/mL,(6.67±2.23)ng/mL,(68.71±23.24)pg/mL,(5.65±1.28)ng/L,(15.65±5.23)U/L in the control group(P<0.05), and the levels of plasma ALB in the study group were significantly lower than those in the control group [(27.69±4.32)U/L vs(45.16±5.65)U/L](P<0.05). With the increase of Child-Pugh grade, the levels of serum s ICAM-1, IL-6, IL-18, TNF-α and plasma ALT increased, and plasma ALB decreased(P<0.05). The levels of serum s ICAM-1, IL-6, IL-18 and TNF-α in patients with hepatitis B and cirrhosis were positively correlated with plasma ALT(all P<0.05),negatively correlated with plasma ALB(all P<0.05). The levels of serum s ICAM-1 in patients with hepatitis B and cirrhosis were positively correlated with IL-6, IL-18 and TNF-α(P<0.05). Conclusion: The levels of s ICAM-1, IL-6, IL-18 and TNF-α in serum of patients with hepatitis B and cirrhosis are increased abnormally, which are related to Child-Pug grade and liver function. The detection of serum s ICAM-1, IL-6, IL-18 and TNF-α may provide a basis for the diagnosis of hepatitis B and cirrhosis and the judgment of the severity of the disease.
作者
熊伟
费润欢
周克湘
张迁
李小燕
XIONG Wei;FEI Run-huan;ZHOU Ke-xiang;ZHANG Qian;LI Xiao-yan(Department of Gastroenterology,The Third Affiliated Hospital of Chongqing Medical University,Chongqing,401120,China;Institute of Digestive Diseases of Whole Army,Southwest Hospital of Army Medical University,Chongqing,400038,China)
出处
《现代生物医学进展》
CAS
2020年第17期3321-3324,共4页
Progress in Modern Biomedicine
基金
重庆市教委科学技术研究项目(KJQN201701303)。
