摘要
背景:3D生物打印为解决组织工程与再生医学领域器官供体匮乏问题提供了新的途径。目的:基于专利信息对全球3D生物打印技术发展态势、技术研发热点、区域布局与合作态势、主要创新主体等进行分析。方法:以德温特专利数据库为数据源,借助Excel、DDA等统计分析工具,从专利年分布、技术研发热点、优先权国、创新主体等维度展开分析。结果与结论:(1)2013年后,3D生物打印技术进入快速发展期,技术热点集中于3D生物打印设备、技术与工艺、生物医用材料、高分子材料等领域;医疗模型构建、医用植入物、药物传输、打印材料、3D打印方法、工艺和流程、医疗器械与设备等是该领域核心技术,中国、美国、韩国专利数量上排名前3;(2)美国在核心技术与产品研发方面引领全球,中国专利数量优势明显,但核心技术专利占有率不高,专利质量和影响力有待提升;(3)国外非常重视国际市场的专利布局,中国对外申请专利较少,全球化竞争意识相对欠缺;(4)各国关注的技术领域存在一定差异,国内研究集中于3D打印设备、系统与组织工程支架等领域;从创新主体看,国外以企业为主导,产业发展基础较好,国内以高校为主导,重视基础研究。
BACKGROUND:Three-dimensional(3D)bio-printing provides a new way to solve the problem of organ donor scarcity in the field of tissue engineering and regenerative medicine.OBJECTIVE:To analyze the development trend of global 3D bio-printing technology,technology research and development hotspot,regional layout and cooperation trend,and main innovation subjects based on patent information.METHODS:Using Derwent Innovation as the data source,this paper conducts analysis on items of patent annual distribution,technology research and development hotspots,priority countries,and innovation subjects with tools of Derwent Data Analyzer and Excel.RESULTS AND CONCLUSION:(1)3D bio-printing technology has entered a period of rapid development after 2013.3D bio-printing equipment,technology and processes,biomedical materials,and polymer materials are the main hotspots.Medical model construction,medical implants,drug delivery,printing materials,3D printing methods,craftsmanship and processes,medical devices and equipment are the core technologies in this field.The most prolific countries are China,the United States,and Korea.(2)The United States is the leader in core technology and product.Although China has a large number of patents,the occupancy of core technology patents is not high,and the quality and influence of patents need to be improved.(3)Foreign countries attach great importance to the layout of patents in the international market.China has fewer foreign patent applications and its global competition awareness is relatively lacking.(4)There are certain differences between countries in the concerned technical fields.Chinese research is focused on areas such as 3D printing equipment,systems,and tissue engineering scaffolds.From the perspective of innovation subject,foreign countries are dominated by enterprises and have a good industrial foundation,while universities are dominated and basic research is valued in China.
作者
凡庆涛
杜赟
周雷
Fan Qingtao;Du Yun;Zhou Lei(Beijing Institute of Science and Technology Information,Beijing 100044,China;Beijing Decision-Making Consultant Center for Science and Technology Strategy,Beijing 100044,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第12期1891-1897,共7页
Chinese Journal of Tissue Engineering Research
基金
2019年度北京市社会科学基金项目(19YJB019),项目名称:北京高精尖产业与传统产业协同发展机制研究,项目参与者:凡庆涛、杜赟、周雷。
关键词
3D
生物打印
组织工程
再生医学
专利信息
发展态势
研发热点
综述
3D
bio-printing
tissue engineering
regenerative medicine
patent information
development trend
research hotspots
review
