摘要
目的研究中性粒细胞CD64结合血常规在重症患者感染性发热与非感染性发热的诊断及鉴别诊断中的意义。方法选取2015年1月至2019年1月于本院治疗的发热患者155例,并根据发热原因分为感染发热组75例和非感染发热组80例。采用流式细胞仪检测所有受试者外周血中性粒细胞CD64指数的水平;采用血液分析仪分别检测所有受试者外周血白细胞(WBC)、降钙素原(PCT)、C-反应蛋白(CRP)水平;采用ROC曲线比较血常规指标的诊断效能。结果感染发热组入院24 h CD64指数和1周CD64指数显著高于非感染发热组,差异具有统计学意义(P<0.05);CD64指数和WBC诊断感染性发热和非感染性发热的敏感度显著高于PCT及CRP,差异具有统计学意义(P<0.05);CD64指数和WBC诊断感染性发热和非感染性发热的特异度显著高于PCT及CRP,差异具有统计学意义(P<0.05)。结论感染性发热患者CD64指数和WBC水平显著升高,且这两种指标在诊断感染性发热与非感染性发热中特异度与敏感度较高,具有较高的诊断价值。
Objective To study the significance of neutrophil CD64 combined with blood routine in diagnosis and differential diagnosis of infectious and non-infectious fever in severe patients.Methods A total of 155 fever patients who were treated in the hospital from between January 2015 and January 2019 were enrolled.According to different fever causes,they were divided into the infectious fever group(75 cases)and the non-infectious fever group(80 cases).The levels of neutrophil CD64 indexes in peripheral blood were detected by flow cytometry.The levels of white blood cells(WBC),procalcitonin(PCT)and C-reactive protein(CRP)in peripheral blood were detected by blood analyzer.The diagnostic efficiency of blood routine indexes was compared by ROC curves.Results After admission,the 24-hour CD64 index and 1-week CD64 index of the infected fever group were significantly higher than those of the non-infected fever group,the difference was statistically significant(P<0.05).The sensitivity of CD64 index and WBC to diagnose infectious and non-infectious fever was significantly higher than that of PCT and CRP,and the difference was statistically significant(P<0.05).The specificity of CD64 index and WBC in diagnosing infectious fever and noninfectious fever was significantly higher than that of PCT and CRP,and the difference was statistically significant(P<0.05).Conclusion The CD64 index and WBC levels of patients with infectious fever are significantly increased,and these two indicators are highly specific and sensitive in the diagnosis of infectious fever and non-infectious fever,and have high diagnostic value.
作者
杜向阳
张文英
闫琳
DU Xiangyang;ZHANG Wenying;YAN Lin(Department of Infectious Diseases,Shandong Provincial Third Hospital,Jinan,Shandong,China,250031;Department Of Emergency,Shandong Provincial Third Hospital,Jinan,Shandong,China,250031;Medical Insurance Office,Shandong Provincial Third Hospital,Jinan,Shandong,China,250031)
出处
《分子诊断与治疗杂志》
2020年第10期1384-1387,共4页
Journal of Molecular Diagnostics and Therapy
基金
山东省自然科学基金项目(ZR2017HL159)。
