摘要
为探讨双歧杆菌三联活菌胶囊联合美沙拉嗪治疗溃疡性结肠炎(UC)的疗效,以及对患者血清炎性指标超敏C反应蛋白(hs-CRP)、血沉(ESR)及血液流变学指标血小板(PLT)、D-二聚体(D-D)水平的影响,将2018年6月至2019年6月我院消化内科收治的100例UC患者随机分为对照组和观察组,各50例,对照组单用美沙拉嗪治疗,观察组联合美沙拉嗪和双歧杆菌三联活菌胶囊治疗,2组均治疗2个月。比较2组患者总体疗效,以及治疗前后hs-CRP、ESR、PLT和D-D水平。结果显示,观察组总有效率(96.00%)明显高于对照组(78.00%),P<0.05。2组治疗前hs-CRP、ESR、PLT、D-D水平比较差异均无统计学意义,P>0.05;治疗后,2组各指标水平均明显下降,P<0.05;治疗后组间比较,观察组各指标明显低于对照组,P<0.05。2组不良反应发生率比较差异无统计学意义,P>0.05。结果表明,与单纯美沙拉嗪治疗UC相比,联合双歧杆菌三联活菌胶囊可提高临床疗效,更好地改善肠黏膜炎症反应及机体高凝状态。
This study was to investigate the effect of bifidobacterium triplet living bacteria capsule(Capsule)plus mesalazine in the treatment of ulcerative colitis(UC),and their influence on patients'serum hs-CRP,ESR,PLT and D-D levels,randomly divided 100UC patients treated in authors'hospital(2018-06-2019-06)into control group(50cases,alone mesalazine for treatment)and observation group(50cases,mesalazine plus Capsule),both treatment for 2months;then,compared both groups'whole effect,as well as the level changes of hs-CRP,ESR,PLT and D-D before and after treatment.As results,in total effective rate observation group was significantly higher than control group(96.00%vs 78.00%,P<0.05);in the levels of hs-CRP,ESR,PLT and D-D before treatment there was no statistical difference between the two groups(P>0.05);but after treatment above all levels of observation group were all significantly lower than that of control group(P<0.05),though both groups'above levels were all significantly declined than before treatment(P<0.05);more than,the untoward reaction incidence of both groups had no statistical difference(P>0.05).Results show that Capsule plus mesalazine in the treatment of UC has more better effect than alone mesalazine,and can better improve patients'superior mesenteric inflammatory response and body's hypercoagulatble state.
作者
魏旭东
WEI Xu-dong(Physical Examination Centre,Zhangye Municipal People's Hospital Affiliated to Hexi Academy,Zhangye,Gansu 734000)
出处
《中国肛肠病杂志》
2020年第8期28-30,共3页
Chinese Journal of Coloproctology
