摘要
目的探讨磁敏感加权成像(SWI)评价肾脏过量铁沉积的价值。方法将30只新西兰大白兔随机分为铁剂组15只(注射右旋糖酐铁)和对照组15只,于铁剂注射前第0周及注射后第8周行T2WI和SWI检查。分析对照组和铁剂组在第0周、第8周影像图像,在相位图上测量肾皮质的相位值并计算角弧度值,并应用普鲁士蓝染色观察肾铁沉积分布、原子吸收分光光度计测量肾铁含量。采用Mann-Whitney U或Wilcoxon检验比较两组间的角弧度值差异,采用独立样本t检验比较两组间的肾铁含量差异。结果铁剂组第8周的肾皮质SWI信号强度显著低于髓质,且显著低于铁剂组第0周和对照组第8周的肾皮质。铁剂组第8周的肾皮质角弧度值[0.2023(0.1618,0.2725)]明显高于铁剂组第0周[-0.0454(-0.0139,0.0080)]和对照组第8周[-0.0112(-0.0529,-0.0014)],差异均有统计学意义(Z=-3.408、-4.666,P均<0.05)。铁剂组第8周的肾皮质内见明显蓝色铁离子沉积、髓质内见极少量蓝色铁离子沉积;铁剂组第8周的肾铁含量[(135.3±14.1)mg/kg]明显高于对照组第8周[(75.5±9.8)mg/kg],差异有统计学意义(t=13.938,P<0.001)。结论SWI可以定量评价肾脏过量铁沉积,过量铁主要沉积于肾皮质,表现为肾皮质SWI信号减低。
Objective To explore the value of susceptibility weighted imaging(SWI)in evaluating renal excess iron deposition.Methods Thirty New Zealand white rabbits were randomly divided into iron group(injected iron dextran)with 15 rabbits and control group with 15 rabbits.All rabbits underwent SWI examination at 0th week before and 8th week after the injection of iron.MRI images of the control and iron group at the 0th and 8th week were analyzed.The phase value of renal cortex was measured on the phase images and the angle radian value was calculated.The distribution of renal iron deposition was observed by Prussian blue stain.The renal iron content was measured by atomic absorption spectrophotometer.The Mann-Whitney U or Wilcoxon test was used to compare the difference in angular radian value between the two groups.The independent sample t test was used to compare the difference in renal iron content between the two groups.Results Only in iron group at 8th week,the SWI signal intensity of renal cortex was significantly lower than that of medulla.The renal cortical SWI signal intensity of iron group at 8th week was significantly lower than that of iron group at 0th week and control group at 8th week,respectively.The angle radian value of iron group at 8th week[0.2023(0.1618,0.2725)]was significantly higher than that of iron group at 0th week[-0.0454(-0.0139,0.0080)]and control group at 8th week[-0.0112(-0.0529,-0.0014)],respectively(Z=-3.408,-4.666,all P<0.05).Only in the iron group at 8th week,the obvious blue iron deposition were observed in renal cortex and few were observed in medulla.The renal iron content[(135.3±14.1)mg/kg]of iron group at 8th week was significantly higher than that[(75.5±9.8)mg/kg]of control group at 8th week(t=13.938,P<0.001).Conclusions SWI can evaluate the excess iron deposition in kidney.Excess iron is mainly deposited in the renal cortex and reduces its SWI signal intensity.The angle radian value calculated from the phase value can quantify the iron deposition.
作者
孙军
沙圆圆
耿薇薇
陈沁
刘琪
陈杰
邢伟
Sun Jun;Sha Yuanyuan;Geng Weiwei;Chen Qin;Liu Qi;Chen Jie;Xing Wei(Department of Radiology,the Third Affiliated Hospital of Soochow University,Changzhou 213001,China)
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2020年第10期1008-1011,共4页
Chinese Journal of Radiology
基金
国家自然科学基金(81771798)
常州市卫生计生委重大科技项目(ZD201806)。
关键词
磁敏感加权成像
肾
铁
Susceptibility weighted imaging
Kidney
Iron
