摘要
目的对北京地区健康人群血清糖化清蛋白(GA)水平进行分析,探讨北京地区健康人群血清GA的参考范围。方法选取2015-2019年来该院体检中心体检经筛选符合要求的健康者4213例作为研究对象,男1942例,女2271例,年龄16~93岁。采用全自动生化分析仪检测血清GA水平。比较不同性别及年龄人群血清GA水平的差异,分析血清GA水平和年龄之间的相关性。结果性别分析显示,女性GA水平高于男性,差异有统计学意义(P<0.01);55岁及以下人群男性GA水平均明显低于同年龄段的女性,差异均有统计学意义(P<0.01);年龄分析显示,65岁以上人群血清GA水平明显增高,与其他年龄段比较,差异均有统计学意义(P<0.01)。血清GA水平与年龄呈正相关(女性:r=0.204,男性:r=0.331,总人群:r=0.357,P<0.01)。本研究中人群血清GA参考范围为10.82%~16.35%,其中男性为10.78%~16.18%,女性为11.34%~16.28%。结论血清GA水平与年龄呈正相关,且存在明显的性别差异,女性GA水平略高于男性。65岁以上人群血清GA水平明显高于65岁及以下人群。
Objective To analyze the serum glycosylated albumin(GA)level of healthy people in Beijing and to explore the reference range of serum GA in healthy people in Beijing.Methods A total of 4213 healthy people(1942 males and 2271 females)aged 16-93 years were selected from the Health Examination Center of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from 2015 to 2019.Blood samples were collected on an empty stomach,and the serum GA level was detected by automatic biochemical analyzer.The sex and age differences of serum GA level were compared,and the correlation between serum GA level and age was analyzed.Results Gender analysis showed that the GA level of female was slightly higher than that of male,and the difference was statistically significant(P<0.01).In population aged 55 and under,GA level of male was lower than that of female at similar age,and the difference was statistically significant(P<0.01).Age analysis showed that the level of serum GA was significantly higher in people over 65 years old compared with patients at other ages(P<0.01).Serum GA level was positively correlated with age(female:r=0.204,male:r=0.331,total population:r=0.357,P<0.01).In this study,the reference range of serum GA was 10.82%-16.35%in the population,among which 10.78%-16.18%in male and 11.34%-16.28%in female.Conclusion Serum GA level is positively correlated with age,and there is a significant gender difference.The level of GA in female is slightly higher than that in male.The level of serum GA in people over 65 years old was significantly higher than that in people under 65 years old.
作者
刘蔚
刘密凤
LIU Wei;LIU Mifeng(Department of Clinical Laboratory,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China)
出处
《国际检验医学杂志》
CAS
2020年第21期2668-2671,2675,共5页
International Journal of Laboratory Medicine
关键词
糖尿病
血清
糖化清蛋白
参考范围
diabetes mellitus
serum
glycosylated albumin
reference interval
