摘要
中医学“骨肉不相亲”理论高度概括了老年性骨质疏松(senile osteoporosis,SOP)骨骼和骨骼肌的内在失衡状态,外泌体作为一种细胞囊泡可携带多种生物活性分子在“骨-肌交联”中发挥关键的调控作用。本文基于“骨肉不相亲”理论探讨骨骼肌源性外泌体在SOP中的作用,对挖掘中医药防治SOP的新靶点及丰富“骨肉不相亲”理论的现代科学内涵具有重要意义。中医学调理脾肾、强肌健骨是治疗SOP“骨肉不相亲”的关键,为防治SOP提供了新的思路。
The theory of disharmony between bone and skeletal muscle in traditional Chinese medicine highly summarizes the status of internal imbalance of bone and skeletal muscle in senile osteoporosis(SOP).Exosomes,a type of extracellular vesicle carrying diverse biological active molecules,play a key regulatory role in bone-muscle crosstalk.In this paper,the molecular mechanism of disharmony between bone and skeletal muscle in SOP is discussed from the perspective of skeletal muscle-derived exosomes regulating bone homeostasis,which is of great significance to explore the new target to prevent and to treat SOP using traditional Chinese medicine and to enrich the modern scientific connotation of the theory of disharmony between bone and skeletal muscle.Regulating spleen and kidney and strengthening muscle and bone in traditional Chinese medicine are the keys to the treatment of SOP,which provide a new idea for the prevention and treatment of SOP.
作者
沈耿杨
黄璇
尚奇
江晓兵
余翔
张志达
招文华
汤凯
梁德
任辉
SHEN Gengyang;HUANG Xuan;SHANG Qi;JIANG Xiaobing;YU Xiang;ZHANG Zhida;ZHAO Wenhua;TANG Kai;LIANG De;REN Hui(The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405;Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou 510405;Guangzhou University of Chinese Medicine, Guangzhou 510405, China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2020年第11期1700-1703,共4页
Chinese Journal of Osteoporosis
基金
广东省自然科学基金(2018A030310615)
广东省高等学校珠江学者岗位计划资助项目(2018年度)
广东省教育厅基础研究及应用基础研究项目(2018KZDXM021)
广东省中医药局科研项目(20191107)
广州中医药大学青年科研培育项目(2019QNPY04)。
关键词
中医中药
老年性骨质疏松
骨痿
骨肉不相亲
骨骼肌源性外泌体
骨稳态
Chinese traditional medicine
senile osteoporosis
bone wilting
disharmony between bone and skeletal muscle
skeletal muscle-derived exosomes
bone homeostasis
