摘要
目的:探讨奥曲肽联合连续性肾脏替代疗法(continuous renal replacement therapy,CRRT)对急性重症胰腺炎患者血清M30及M65表达的影响。方法:选取2016年2月至2019年4月邢台市第三医院急诊科收治的急性重症胰腺炎患者126例,根据随机数字表法分为对照组和观察组。对照组患者给予常规治疗联合CRRT治疗,观察组患者在对照组的基础上给予醋酸奥曲肽注射液。治疗2周后比较两组患者免疫球蛋白(Ig)、内毒素、炎症因子、生化指标及血清M30、M65水平的差异。结果:治疗2周后,观察组患者的总有效率为90.48%(57/63),明显高于对照组的68.25%(43/63),差异有统计学意义(P<0.05)。治疗2周后,两组患者血清内毒素水平,炎症因子C反应蛋白、白细胞介素6及肿瘤坏死因子α水平,生化指标血清淀粉酶、糖酵解酶水平,血清M30及M65水平较治疗前明显降低,且观察组患者上述指标水平与对照组相比明显更低,差异均有统计学意义(P<0.05);而两组患者IgM、IgA及IgG水平,炎症因子白细胞介素10(IL-10)水平较治疗前明显升高,且观察组患者IgM、IgG及IL-10水平明显高于对照组,差异均有统计学意义(P<0.05)。结论:奥曲肽联合CRRT能够有效降低急性重症胰腺炎患者血清M30、M65的表达,缓解炎症反应,保护胰腺组织,治疗效果显著。
OBJECTIVE: To probe into the effect of octreotide combined with continuous renal replacement therapy( CRRT) on the expression of serum M30 and M65 in patients with acute severe pancreatitis. METHODS: Totally 126 patients with acute severe pancreatitis admitted into the emergency department of the Third Hospital of Xingtai City from Feb. 2016 to Apr. 2019 were selected and divided into control group and observation group via random number table. The control group was given conventional therapy combined with CRRT,while the observation group was treated with octreotide acetate injection based on the control group. Differences in immune globulin,endotoxin,inflammatory factor,biochemical criterion,serum M30 and M50 levels were compared between two groups at 2 weeks after treatment. RESULTS: At 2 weeks after treatment,the total effective rate of observation group was 90. 48%( 57/63),which was significantly higher than that of the control group( 68. 25%,43/63),with statistically significant difference( P < 0. 05). At 2 weeks after treatment,the serum endotoxin,inflammatory factor( C reaction protein,interleukin 6 and tumor necrosis factor α),biochemical criterion( serum amylase,glycolytic enzyme),serum M30 and M65 levels of both groups had been significantly decreased,and those of the observation group were significantly lower than the control group,with statistically significant differences( P < 0. 05);while the immune globulin( IgM,IgA and IgG)and inflammatory factor( interleukin 10) levels of both groups had been significantly increased,the IgM,IgG and IL-10 levels of observation group were significantly higher than those of the control group,with statistically significant differences( P < 0. 05). CONCLUSIONS: The combination of octreotide and CRRT can significantly reduce the expression of serum M30 and M65 in patients with acute severe pancreatitis,relieve inflammatory reaction,protect pancreatic tissue,with remarkable therapeutic effect.
作者
平立英
周哲
杨素云
王康
齐文美
PING Liying;ZHOU Zhe;YANG Suyun;WANG Kang;QI Wenmei(Dept.of Nephrology,the Third Hospital of Xingtai City,Hebei Xingtai 054000,China;Dept.of Emergency,the Third Hospital of Xingtai City,Hebei Xingtai 054000,China)
出处
《中国医院用药评价与分析》
2020年第10期1204-1207,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
邢台市科技计划项目(No.2019ZC210)。
