摘要
目的观察两种血液净化方式对慢性肾功能衰竭尿毒症患者肾功能指标及相关并发症的影响。方法回顾性分析2018年1月至2019年12月首都医科大学附属北京世纪坛医院收治的慢性肾功能衰竭尿毒症患者64例,采用随机数字表法分为观察组与对照组,各32例,分别采用血液透析滤过联合血液灌流治疗与血液透析滤过治疗。比较2组患者治疗前、治疗后肾功能指标变化情况、水电解质指标以及并发症发生情况。结果治疗后2组患者肾功能指标、水电解质水平均较治疗前有所改善,差异有统计学意义(P<0.05);治疗后观察组患者红细胞沉降率(ESR)、尿蛋白、血肌酐(Cr)、血(BUN)指标分别为(15.26±5.56)mm/h、(0.42±0.14)g/24 h、(996.67±34.52)μmol/L、(10.37±1.02)μmol/L,均低于对照组[(28.97±5.63)mm/h、(0.98±0.46)g/24 h、(1023.87±35.37)μmol/L、(11.13±1.47)μmol/L],差异有统计学意义(P<0.05)。观察组患者治疗后K+、Na+、CL分别为(4.21±0.56)mmol/L、(121.02±10.24)mmol/L、(73.79±8.12)mmol/L,低于对照组的(4.64±0.63)mmol/L、(134.38±10.26)mmol/L、(87.97±9.37)mmol/L,差异有统计学意义(P<0.05)。观察组患者治疗后6例出现并发症,发生率18.75%,高于对照组的37.50%(12/32)差异有统计学意义(P<0.05)。结论慢性肾功能衰竭尿毒症患者行血液透析滤过联合血液灌流治疗,有利于纠正水电解质平衡、改善肾功能,且并发症发生率低,可予以推广。
Objective To observe the effects of two blood purification methods on renal function indexes and related complications in patients with uremia in chronic renal failure.Methods A retrospective analysis was made on 64 uremic patients with chronic renal failure admitted to our hospital from January 2018 to December 2019.They were divided into two groups by random number table method.32 patients in the observation group and the control group were treated by hemodialysis filtration combined with hemoperfusion and hemodialysis filtration respectively.The changes of renal function index,water electrolyte index and complications of the two groups were compared before and after treatment.Results The indexes of ESR,urinary protein,blood Cr and blood bun in the observation group were(15.26±5.56)mm/h,(0.42±0.14)g/24 h,(996.67±34.52)μmol/L and(10.37±1.02)μmol/L respectively,which were lower than those in the control group[(28.97±5.63)mm/h,(0.98±0.46)g/24 h,(1023.87±35.37)μmol/L,(11.13±1.47)μmol/L],the differences were statistically significant(P<0.05).After treatment,K+,Na+and Cl in the observation group were(4.21±0.56)mmol/L,(121.02±10.24)mmol/L,(73.79±8.12)mmol/L,respectively,which were lower than those in the control group(4.64±0.63)mmol/L,(134.38±10.26)mmol/L,(87.97±9.37)mmol/L,the differences were statistically significant(P<0.05).Complications occurred in 6 patients in the observation group after treatment,accounting for 18.75%,which was lower than 37.50%in the control group(12/32),and the difference was statistically significant(P<0.05).Conclusion The treatment of hemodialysis and hemoperfusion in uremic patients with chronic renal failure is beneficial to correct the balance of water and electrolyte,improve renal function,and has few complications,which can be popularized.
作者
刘博
王亚丽
柳冰
LIU Bo;WANG Ya-li;LIU Bing(Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)
出处
《临床和实验医学杂志》
2020年第21期2319-2322,共4页
Journal of Clinical and Experimental Medicine
基金
国家自然科学基金青年项目(编号:81700007)。
