摘要
目的:观察胃炎康胶囊联合铝碳酸镁治疗胆汁反流性胃炎患者的效果。方法:选取80例胆汁反流性胃炎患者作为研究对象,依据随机数字表法分为对照组和观察组各40例。对照组采用铝碳酸镁治疗,观察组在对照组基础上联合胃炎康胶囊治疗。连续用药4周,比较两组治疗前后胃镜检查结果、临床症状总积分、生存质量评分、临床疗效和血清白细胞介素-6(IL-6)、血管活性肠肽(VIP)水平,及不良反应发生率。结果:治疗后,观察组胃黏膜充血、糜烂、水肿评分均明显低于对照组,差异有统计学意义(P<0.05);治疗后,观察组临床症状总积分与生存质量评分均明显低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.00%,明显高于对照组的77.50%,差异有统计学意义(P<0.05);治疗后,观察组血清VIP、IL-6水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组均未发生明显不良反应。结论:胃炎康胶囊联合铝碳酸镁治疗胆汁反流性胃炎患者,可保护机体胃黏膜,改善临床症状,提高生存质量,且不会增加不良反应。
Objective:To observe effects of Weiyankang capsules combined with Aluminum magnesium carbonate on patients with bile reflux gastritis.Methods:80 patients with bile reflux gastritis were selected as the research objects,and divided into control group and observation group according to the random number table method,each with 40 cases.The control group was treated with Aluminum magnesium carbonate,while the observation group was treated with Weiyankang capsules on the basis of that of the control group.The treatment lasted for 4 weeks.The results of gastroscopy,total score of clinical symptoms,quality of life score,treatment effects,the levels of serum interleukin-6(IL-6)and vasoactive intestinal peptide(VIP),and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the scores of gastric mucosal congestion,erosion and edema in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the total score of clinical symptoms and quality of life score in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 95.00%,which was significantly higher than 77.50%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of serum VIP and IL-6 in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).During the treatment period,no obvious adverse reactions occurred in the two groups.Conclusions:For the patients with bile reflux gastritis,Weiyankang capsules combined with Aluminum magnesium carbonate can protect the gastric mucosa,improve the clinical symptoms,and improve the quality of life without increasing the adverse reactions.
作者
赵敏
ZHAO Min(Department of Spleen and Stomach Disease of Liaoning University of Traditional Chinese Medicine Hospital Subsidiary Fourth,Shenyang 110101 Liaoning,China)
出处
《中国民康医学》
2020年第19期79-81,共3页
Medical Journal of Chinese People’s Health
关键词
胆汁反流性胃炎
胃炎康胶囊
铝碳酸镁
Bile reflux gastritis
Weiyankang capsules
Aluminum magnesium carbonate
