摘要
目的通过孕早期超声检测蒙、汉民族胎儿颈项透明层厚度(NT)与胎儿异常的相关性,探讨其在预测两民族间胎儿异常的差异性。方法选2013年6月至2017年12月来我院产前检查的孕11~13+6周、胎儿头臀径为45~84 mm的妊娠妇女6000例,蒙古族和汉族各半,年龄25~40岁,产科超声测量胎儿NT的厚度,大于3 mm为异常增厚者纳入研究,追踪随访孕妇不良妊娠结局,记录异常胎儿发生情况,行统计学分析。结果孕妇产科超声发现蒙古族胎儿NT增厚者76例(2.53%)中,最终出现妊娠不良结局者25例(32.89%),其中自行行其他筛查人为终止妊娠者15例(19.73%),自然流产3例(3.94%),产后经产科医师及新生儿科医师随访诊断先天畸形者5例(6.57%),死胎2例(2.63%);汉族胎儿NT增厚者81例(2.70%)中,发现妊娠不良结局者27例(33.33%),其中人为终止妊娠者17例(20.98%),自然流产4例(4.93%),死胎2例(2.46%),产后诊断先天畸形者4例(4.93%)。NT增厚者共失访4例。统计学分析后发现,蒙古族胎儿NT增厚者较汉族少,但差别无统计学意义(P>0.05),NT增厚的胎儿中出现不良结局者蒙古族较汉族少,但差别无统计学意义(P>0.05)。结论孕早期蒙古族胎儿NT增厚者较汉族少,出现不良妊娠结局者较汉族少,但差别均无统计学意义(P>0.05)。
Objective To investigate the correlation between fetal abnormality and nuchal translucency(NT)thickness detected by ultrasound in early pregnancy in Mongolian and Han nationalities,and to explore the difference in predicting fetal abnormality between the two nationalities.Methods From June 2013 to December 2017,6000 pregnant women aged 11~13+6 weeks and 45~84 mm in fetal head and buttock length,half of Mongolian and half of Han nationalities,aged 25~40 years,were selected for prenatal examination in our hospital.The thickness of fetal NT was measured by obstetric ultrasound.Abnormal thickness is greater than 3 mm.Follow-up of adverse pregnancy outcomes of pregnant women.The occurrence of abnormal fetuses with definite diagnosis was recorded and analyzed statistically.Lost interviewees were excluded.Results Among 76 cases(2.53%)of Mongolian fetal NT thickening detected by obstetric ultrasound,25 cases(32.89%)eventually had adverse pregnancy outcomes,including 15 cases(19.73%)of artificial termination of pregnancy byself-screening,3 cases(3.94%)of spontaneous abortion,5 cases(6.57%)of congenital malformation diagnosed by postpartum obstetricians and neonatologists,and 2 cases(2.63%)of stillbirth.among 81 cases(2.70%)with NT thickening,27 cases(33.33%)had adverse pregnancy outcomes,including 17 cases(20.98%)of artificial termination of pregnancy,4 cases(4.93%)of spontaneous abortion,2 cases(2.46%)of stillbirth and 4 cases(4.93%)of postpartum diagnosis of congenital malformation.Four patients with NT thickening were lost to follow-up.Statistical analysis found that the Mongolian fetus NT thickening less than the Han,but there was no significant difference(P>0.05),NT thickening in the fetus of Mongolian fewer adverse outcomes than the Han,but the difference was not statistically significant(P>0.05).Cconclusion There were fewer cases of NT thickening in Mongolian fetuses in early pregnancy and fewer cases of adverse pregnancy outcomes in Mongolian fetuses than in Han fetuses,but the difference was not statistically significant(P>0.05).
作者
李艳芬
吕宏岩
王丽娜
甄以惠
张春丽
马丽蓉
于彩琴
LI Yan-fen;LV Hong-yan;WANG Li-na;ZHEN YI Hui;ZHANG Chun-li;MA Li-rong;YU Cai-qin(Inner Mongolia Autonomous Region people's Hospital,Hohhot 010017 China)
出处
《内蒙古医学杂志》
2020年第9期1028-1030,F0004,共4页
Inner Mongolia Medical Journal
基金
内蒙古自治区科学技术厅资助项目(编号:20130404)。
