摘要
目的:探讨血小板-淋巴细胞比率(PLR)、中性粒细胞-淋巴细胞比率(NLR)及红细胞分布宽度(RDW)在冠心病(CHD)患者疾病严重程度中的诊断价值。方法:选取2018-05-2019-10在我院进行冠状动脉造影(CAG)检查的患者170例,根据检查结果分为CHD组(130例)与对照组(非CHD组,40例);并按冠状动脉狭窄程度(Gensini)积分,将130例CHD患者分为CHD低危组(45例)、CHD中危组(50例)及CHD高危组(35例)。比较4组研究对象PLR、NLR、RDW水平及Gensini积分,采用Pearson法分析PLR、NLR、RDW水平与Gensini积分相关性,采用受试者工作特征(ROC)曲线检测PLR、NLR、RDW指标单独及联合诊断对CHD患者病情严重程度的诊断价值。结果:3组CHD患者PLR、NLR及RDW水平均明显高于对照组(P<0.05),CHD患者Gensini积分、PLR、NLR及RDW水平均随病情严重程度的增加而上升(P<0.05);CHD患者PLR、NLR及RDW水平与Gensini积分呈正相关(r=0.439、0.431、0.573,P<0.05);PLR、NLR、RDW单独及联合诊断CHD患者病情严重程度的AUC值分别为0.782、0.776、0.767及0.875。结论:机体内PLR、NLR、RDW水平可作为评估冠状动脉病变程度的指标,与CHD患者病情严重程度密切相关。
Objective:To explore the diagnostic value of platelet-lymphocyte ratio(PLR),neutrophil-lymphocyte ratio(NLR) and red blood cell distribution width(RDW) in the severity of coronary heart disease(CHD).Method:A total of 170 patients who underwent coronary angiography(CAG) from May.2018 to Oct.2019 were selected and divided into CHD group(n=130) and control group(Non-CHD group,n=40).According to the degree of coronary artery stenosis(Gensini) score,130 patients with CHD were divided into CHD low-risk group(n=45),CHD intermediate-risk group(n=50) and CHD high-risk group(n=35).The PLR,NLR,and RDW levels of four groups were compared,and the Pearson method was used to analyze the correlation.The receiver operating characteristic(ROC) curve was used.Result:The expression levels of PLR,NLR,and RDW in the three groups of CHD patients were significantly higher than those in the control group(P<0.05).The levels of Gensini score,PLR,NLR and RDW increased with the severity of CHD patients(P<0.05).PLR,NLR and RDW levels in patients with CHD were positively correlated with Gensini scores(r=0.439,0.431,0.573,P<0.05).The AUC values of PLR,NLR,RDW combined and separately diagnosed in patients with CHD were 0.782,0.776,0.767,and 0.875.Conclusion:The levels of PLR,NLR,and RDW in the body can be used as indicators to assess the degree of CHD,which is closely related to the severity of CHD patients.
作者
张林
陈玥
张宝红
ZHANG Lin;CHEN Yue;ZHANG Baohong(Department of Laboratory Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing,100050,China)
出处
《临床心血管病杂志》
CAS
北大核心
2020年第9期824-827,共4页
Journal of Clinical Cardiology
