摘要
目的探究幽门螺杆菌(Hp)感染与结直肠腺瘤(CRA)患者临床特征的关系及对肠道菌群的影响。方法选取2017年1月-2019年9月三亚市人民医院104例CRA患者作为病例组,另选同期健康体检者110名作为对照组。比较两组一般资料、Hp感染阳性率、肠道菌检出数量,分析CRA发生的相关因素,探究Hp感染与CRA患者临床特征的关系。结果病例组Hp感染阳性率高于对照组(P<0.05);CRA的发生与高脂血症、CRA家族史、Hp感染具有密切关系(P<0.05);CRA Hp感染阳性患者腺瘤直径大于Hp阴性患者,腺瘤伴高级别上皮内瘤变发生率高于Hp阴性患者(P<0.05);病例组粪肠球菌、大肠埃希菌检出数量高于对照组,乳酸杆菌、双歧杆菌、弯曲杆菌检出数量低于对照组(P<0.05);病例组Hp阳性患者粪肠球菌、大肠埃希菌检出数量高于Hp阴性患者,乳酸杆菌、双歧杆菌、弯曲杆菌检出数量低于Hp阴性患者(P<0.05)。结论Hp感染与CRA的发生及临床特征关系密切,且能加重患者肠道菌群的紊乱,通过抑制Hp感染,有助于调节肠道菌群平衡,促进患者预后改善。
OBJECTIVE To explore the correlation between Helicobacter pylori infection and clinical characteristics of patients with colorectal adenoma(CRA)and observe the effect on intestinal flora.METHODS Totally 104patients with CRA who were treated in Sanya People’s Hospital from Jan.2017to Sep.2019were assigned as the case group,meanwhile,110healthy people who received physical examination were set as the control group.The baseline data,positive rate of H.pylori infection and counts of intestinal flora were compared between the two groups,the related factors for CRA were analyzed,and the relationship between the H.pylori infection and the clinical characteristics of the CRA patients was explored.RESULTS The positive rate of H.pylori infection of the case group was significently higher than that of the control group(P<0.05).The incidence of CRA was closely associated with hyperlipidemia,family history of CRA and H.pylori infection(P<0.05).The diameter of adenoma was significently higher in the Hp-positive CRA patients than in the Hp-negative patients,and the incidence of adenoma with high-grade intraepithelial neoplasia was significently higher in the Hp-positive CRA patients than in the Hp-negative patients(P<0.05).The colony counts of isolated Enterococcus faecalis and Escherichia coli were significently greater in the case group than in the control group;the colony counts of isolated Lactobacillus,Bifidobacterium and Campylobacter were less than in case group than in the control group(P<0.05).In the case group,the colony counts of the isolated E.faecalis and E.coli of the Hp-positive patients were significently greater than those of the Hp-negative patients,and the colony counts of Lactobacillus,Bifidobacteriumand Campylobacter of the Hp-positive patients were significently less than those of the Hp-negative patients(P<0.05).CONCLUSIONThe H.pylori infection is closely associated with the incidence of CRA and clinical characteristics,aggravate the disorder of intestinal flora,facilitate the regulation of balance of intestinal flora and promote the improvement of prognosis by inhibiting the H.pylori infection.
作者
李文刚
周运王
张学政
饶卉明
符亮
LI Wen-gang;ZHOU Yun-wang;ZHANG Xue-zheng;RAO Hui-ming;FU Liang(Sanya People's Hospital,Sanya,Hainan 572000,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2020年第20期3095-3098,共4页
Chinese Journal of Nosocomiology
基金
海南省三亚市医疗卫生科技创新基金资助项目(2017YW2831)。
关键词
结直肠腺瘤
结直肠癌
幽门螺杆菌
感染
肠道菌群
Colorectal adenoma
Colorectal cancer
Helicobacter pylori
Infection
Intestinal flora
