摘要
目的:探讨血清血管紧张素转化酶(ACE)联合结核感染T细胞斑点试验(T-SPOT)中的结核特异性抗原(TBAg)与植物血凝素(PHA)比值对活动性肺结节病的诊断价值。方法:回顾性选取活动性肺结节病患者44例为病例组,选取肺结核患者30例和非结节病非结核患者20例为对照组,比较3组患者血清ACE水平和TBAg/PHA比值,采用受试者工作特征(ROC)曲线下面积(AUC)评价血清ACE水平、TBAg/PHA比值及两者联合对活动性肺结节病的诊断价值。结果:活动性肺结节病组患者血清ACE水平显著高于对照组(P<0.01),肺结核组患者TBAg/PHA比值显著高于活动性肺结节病组和非结节病非结核对照组(均P<0.01)。以非结节病患者为对照,血清ACE水平、TBAg/PHA比值及两者联合对活动性肺结节病诊断的AUC分别为0.871、0.723和0.921,以肺结核患者为对照,其AUC分别为0.855、0.823和0.930,以非结节病非结核患者为对照,其AUC分别为0.894、0.573和0.902。结论:血清ACE水平和结核T-SPOT中的TBAg/PHA比值两者联合对活动性肺结节病具有更高的诊断价值。
Objective:To investigate the diagnostic value of serum angiotensin converting enzyme(ACE)combined with ratio of tuberculosisspecific antigen(TBAg)to phytohemagglutinin(PHA)in T-SPOT for active pulmonary sarcoidosis.Methods:The patients with active pulmonary sarcoidosis were selected retrospectively as the case group(n=30),those with tuberculosis(n=30)and those with non-sarcoidosis non-tuberculosis(n=20)served as the control group.The levels of serum ACE and TBAg/PHA ratio were compared.The receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of ACE,TBAg/PHA ratio and their combination.Results:The levels of ACE in active pulmonary sarcoidosis group were significantly higher than in the control group(P<0.01).The TBAg/PHA ratio in the tuberculosis group was significantly higher than in active sarcoidosis group and non-sarcoidosis non-tuberculosis group(P<0.01).Using non-sarcoidosis patients as controls,the area under the ROC curve(AUC)of serum ACE,TBAg/PHA ratio and their combination for the diagnosis of active pulmonary sarcoidosis was 0.871,0.723 and 0.921,respectively.Using pulmonary tuberculosis patients as controls,the AUC of serum ACE,TBAg/PHA ratio and their combination for the diagnosis of active pulmonary sarcoidosis was 0.855,0.823 and 0.930,respectively.Using non-sarcoidosis non-tuberculosis patients as controls,the AUC of serum ACE,TBAg/PHA ratio and their combination for the diagnosis of active pulmonary sarcoidosis was 0.894,0.573 and 0.902,respectively.Conclusions:The combination of serum ACE and TBAg/PHA ratio in T-SPOT has a higher diagnostic value for active pulmonary sarcoidosis.
作者
高姝佩
陈晋卿
王坚苗
GAO Shu-pei;CHEN Jin-qing;WANG Jian-miao(Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《内科急危重症杂志》
2020年第5期372-375,共4页
Journal of Critical Care In Internal Medicine
基金
国家自然科学基金面上项目(81670035)。
