摘要
目的观察天麻素注射液联合帕罗西汀治疗抑郁症患者的临床疗效。方法选取2019年1—6月在河北省人民医院确诊的抑郁症患者90例,按照随机数表法分为观察组和对照组,每组45例。对照组给予帕罗西汀肠溶缓释片口服4周,观察组给予帕罗西汀肠溶缓释片4周联合天麻素注射液静滴2周。观察2组治疗2周、4周汉密尔顿抑郁量表(HAMD)评分、抑郁自评量表(SDS)评分、焦虑自评量表(SAS)评分及治疗4周后中医症状(少寐多梦、眠浅易醒、心烦易怒、情绪低落、郁郁寡欢、倦怠乏力)积分、症状自评量表评分(SCL-90)总分变化,统计2组临床疗效及治疗期间不良反应发生情况。结果治疗2周后,2组患者HAMD、SDS、SAS评分均较治疗前明显下降(P均<0.05),治疗4周后均明显低于治疗2周后(P均<0.05),且观察组各评分均明显低于同期对照组(P均<0.05)。治疗4周后,2组患者中医症状评分及SCL-90总分均较治疗前明显降低(P均<0.05),且观察组治疗后各项评分均明显低于对照组(P均<0.05)。治疗4周后,观察组临床总有效率为91.1%(41/45),对照组为73.3%(33/45),2组比较差异有统计学意义(P<0.05);观察组患者不良反应发生率为15.6%(7/45),对照组为11.1%(5/45),2组比较差异无统计学意义(P>0.05)。结论天麻素注射液联合帕罗西汀可缓解焦虑抑郁状态,显著改善抑郁症患者中医症状,疗效显著优于单纯帕罗西汀治疗,且安全性高。
Objective It is to observe the clinical efficacy of gastrodin injection combined with paroxetine in the treatment of patients with depression.Methods Ninety patients with depression diagnosed in Hebei General Hospital from January to June 2019 were selected and divided into observation group and control group according to the random number table method,with 45 cases in each group.The control group was given paroxetine enteric-coated sustained-release tablets orally for 4 weeks,and the observation group was given paroxetine enteric-coated sustained-release tablets orally for 4 weeks combined with gastrodin injection intravenously for 2 weeks.The changes of the scores of Hamilton Depression Scale(HAMD),Self-Rating Depression Scale(SDS),and Self-Rating Anxiety Scale(SAS)after treatment for 2 weeks and 4 weeks,and the scores of TCM syndromes(less sleep and more dreams,light sleep and easy to wake up,upset and irritable,low mood,depression,fatigue)and total scores of symptom self-rating scale(SCL-90)after treatment for 4 weeks were observed in the two groups,the clinical efficacy of the two groups were evaluated and the occurrence of adverse reactions during treatment were counted.Results After 2 weeks of treatment,the scores of HAMD,SDS,and SAS of the patients in the two groups were significantly lower than those before treatment(P<0.05),and after 4 weeks of treatment,they were significantly lower than those after 2 weeks of treatment(P<0.05),and the scores in the observation group were significantly lower than those in the control group in the same period(P<0.05).After 4 weeks of treatment,the scores of TCM syndromes and the total score of SCL-90 in the two groups were significantly lower than those before treatment(P<0.05),and the scores of the observation group after treatment were significantly lower than those of the control group(P<0.05).After 4 weeks of treatment,the total clinical effective rate was 91.1%(41/45)in the observation group and 73.3%(33/45)in the control group,the difference between the two groups was statistically significant(P<0.05).The incidence rate of adverse reactions was 15.6%(7/45)in the observation group and 11.1%(5/45)in the control group,there was no significant difference between the two groups(P>0.05).Conclusion The combination of gastrodin injection and paroxetine can relieve anxiety and depression,significantly improve the symptoms of TCM in patients with depression,its curative effect is significantly better than that of paroxetine alone,and the safety is high.
作者
倪爱华
费迪
金曼
翟晓艳
张雪茹
张石盼
NI Aihua;FEI Di;JIN Man;ZHAI Xiaoyan;ZHANG Xueru;ZHANG Shipan(Hebei General Hospital,Shijiazhuang 050051,Hebei,China)
出处
《现代中西医结合杂志》
CAS
2020年第33期3654-3657,3692,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
河北省中医药管理局科研计划项目(2019145)。
