摘要
目的评价CYFRA21-1与BTA stat检测在膀胱癌诊断中的价值。方法选2019年6~12月在我院经病理学检查确诊的膀胱癌患者57例为实验组,选同期泌尿系统良性疾病患者66例为良性疾病对照组,选健康体检者30名为健康对照组,比较三组血清CYFRA21-1值和尿BTA stat结果;实验组不同病理分期、临床分期的血清CYFRA21-1值和尿BTA stat结果;血清CYFRA21-1和尿BTA stat检测单独和联合诊断的敏感性、特异性、阳性预测值、阴性预测值。结果膀胱癌组CYFRA21-1阳性率为68.40%、BTA stat检测的阳性率为85.96%,均高于泌尿系统良性疾病组(CYFRA21-1阳性率13.60%、BTA stat检测的阳性率25.76%)和健康对照组(CYFRA21-1阳性率6.70%、BTA stat检测的阳性率0);实验组CYFRA21-1的敏感性随着膀胱癌临床分期、病理分级的升高而增加。BTA stat检测的阳性率随着临床分期的升高而增加,但在不同病理分级中无此变化;CYFRA21-1单独检测敏感性低于BTA stat检测(68.40%vs 85.96%),特异性略高于BTA stat检测(88.54%vs 82.29%);两者做平行试验的敏感性较高,为92.98%,两者系列试验的特异性较高,为92.71%。结论血清CYFRA21-1与尿液BTA stat检测可用于膀胱癌的诊断,两者联合检测有助于提高敏感性及特异性。
Objective To evaluate the value of CYFRA21-1 and BTA stat in the diagnosis of bladder cancer.Methods 57 bladder cancer patients diagnosed by pathological examination in our hospital from June 2019 to December 2019 were selected as the experimental group,66 patients with benign urinary system diseases during the same period were selected as the control group with benign diseases,and 30 healthy subjects were selected as a healthy control group,compare the serum CYFRA21-1 values and urine BTA stat results of the three groups;the serum CYFRA21-1 values and urine BTA stat results of different pathological and clinical stages of the experimental group;the sensitivity of serum CYFRA21-1 and urine BTA stat detection alone and combined diagnosis,specificity,positive predictive value,negative predictive value.Results The positive rate of CYFRA21-1 in the bladder cancer group was 68.40%,and the positive rate of BTA stat was 85.96%,which were higher than those in the urinary system benign disease group(CYFRA21-1 positive rate was 13.60%,BTA stat positive rate was 25.76%)and healthy control group(CYFRA21-1 positive rate 6.70%,BTA stat positive rate 0);experimental group CYFRA21-1 sensitivity increased with the increase of clinical stage and pathological grade of bladder cancer.The positive rate of BTA stat test increases with the increase of clinical stage,but there was no such change in different pathological grades;the sensitivity of CYFRA21-1 alone was lower than that of BTA stat test(68.40%vs 85.96%),and the specificity was slightly higher detected by BTA stat(88.54%vs 82.29%);the sensitivity of the two parallel tests was higher,92.98%,and the specificity of the two series of tests was higher,92.71%.Conclusion The detection of serum CYFRA21-1 and urine BTA stat can be used for the diagnosis of bladder cancer,and the combined detection of the two helps to improve the sensitivity and specificity.
作者
熊雄
熊斌
姚烽
XIONG Xiong;XIONG Bin;YAO Feng(Department of Urology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400042,China;Department of Urology,Nanchuan District People's Hospital,Chongqing 408400,China;Department of Urology,Banan District People's Hospital,Chongqing 401320,China)
出处
《医学信息》
2020年第22期104-106,共3页
Journal of Medical Information
