摘要
目的探讨急诊中暑患者早期应用地塞米松治疗的效果。方法收集2017年1月~2019年12月我院急诊收治的48例中暑患者临床资料,按照治疗方法不同分为对照组22例和观察组26例。对照组采用常规疗法治疗,观察组采用常规疗法+地塞米松治疗,比较两组临床症状及重要脏器功能改善时间、动脉血气指标[碳酸氢根(HCO3^-)、动脉血氧分压(PaO2)、血氧饱和度(SaO2)]水平、相关生化指标[血清肌酐(Scr)、活化部分凝血活酶时间(APTT)、肌酸激酶同工酶(CK-MB)]水平及不良反应发生率。结果观察组体温恢复正常、肝肾功能恢复正常、心肌酶恢复正常及临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);观察组HCO3^-、PaO2、SaO2水平高于对照组,差异有统计学意义(P<0.05);观察组Scr、APTT水平低于对照组,CKMB水平高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为7.69%,与对照组的9.09%比较,差异无统计学意义(P>0.05)。结论急诊中暑患者早期应用地塞米松治疗能够有效缩短临床症状及重要脏器功能改善时间,改善动脉血气及生化指标异常水平,且不会增加不良反应发生率,安全性较好。
Objective To investigate the effect of dexamethasone treatment in emergency heatstroke patients.Methods To collect the clinical data of 48 cases of heatstroke patients admitted in our hospital from January 2017 to December 2019,the data of 22 patients treated with conventional therapy were included in the control group,26 patients treated with routine dexamethasone were included in the observation group.The clinical symptoms and organ function improvement time,arterial blood gas index(HCO3-),arterial blood oxygen partial pressure(PaO2),blood oxygen saturation(SaO2)were compared between the two groups[serum creatinine(Scr),activated partial thromboplastin time(APTT),creatine kinase isoenzyme(CK-MB)]levels and incidence of adverse reactions.Results The observation group's body temperature returned to normal,liver and kidney function returned to normal,myocardial enzymes returned to normal,and the disappearance of clinical symptoms were shorter than the control group,the difference was statistically significant(P<0.05);the observation group's HCO3-,PaO2,and SaO2 levels were higher than the control group,the difference was statistically significant(P<0.05);the level of Scr and APTT in the observation group was lower than that of the control group,and the level of CK-MB was higher than that of the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 7.69%,compared with 9.09%in the control group,the difference was not statistically significant(P>0.05).Conclusion Early application of dexamethasone in emergency heatstroke patients can effectively shorten the improvement time of clinical symptoms and important organ function,improve the abnormal level of arterial blood gas and biochemical indexes,and do not increase the incidence of adverse reactions,and the safety is good.
作者
吴强
WU Qiang(Naval Hospital No.971 Third Outpatient Department,Qingdao 266041,Shandong,China)
出处
《医学信息》
2020年第22期156-157,160,共3页
Journal of Medical Information
关键词
中暑
地塞米松
临床症状改善时间
动脉血气水平
Heatstroke
Dexamethasone
Time to improve clinical symptoms
Arterial blood gas level
