摘要
目的:探讨疏风解毒胶囊对风热犯肺型慢性支气管炎急性发作患者炎性因子及临床疗效的影响。方法:选取2018年1月至2020年4月中国人民解放军联勤保障部队第904医院收治的风热犯肺型慢性支气管炎急性发作患者112例作为研究对象,按照随机数字表法随机分为观察组和对照组,每组56例。观察组给予疏风解毒胶囊联合注射用哌拉西林钠他唑巴坦钠、盐酸氨溴索、布地奈德混悬液、吸入用乙酰半胱氨酸溶液进行治疗,对照组给予注射用哌拉西林钠他唑巴坦钠、盐酸氨溴索、布地奈德混悬液、吸入用乙酰半胱氨酸溶液治疗。比较2组炎性反应因子、外周血WBC水平、临床症状消失时间及疗效等。结果:治疗后,观察组和对照组TNF-α、CRP水平均较治疗前降低(P<0.05),且观察组均低于对照组(P<0.05);治疗后,观察组和对照组WBC、N%水平均较治疗前降低(P<0.05);治疗后,对照组啰音消失时间、平均治愈时间均长于观察组(P<0.05);观察组总有效率为91.07%,高于对照组的75.24%(P<0.05)。结论:疏风解毒胶囊联合常规西药治疗能有效抑制风热犯肺型慢性支气管炎急性发作期患者体内的炎性反应,发挥显著的抗感染作用,改善患者临床症状,促进疾病恢复。
Objective:To explore the effects Shufeng Jiedu Capsules on inflammatory factors and clinical efficacy in patients with acute attack of chronic bronchitis of wind-heat attacking lung type.Methods:A total of 112 patients with acute attack of chronic bronchitis of wind-heat attacking lung type admitted to 904th Hospital of the Joint Service Support Force of the Chinese People′s Liberation Army Hospital from January 2018 to April 2020 were selected as the research objects and were divided into an observation group and a control group,with 56 cases in each group.The observation group was treated with Shufeng Jiedu Capsules combined with piperacillin sodium tazobactam sodium for injection,ambroxol hydrochloride,budesonide suspension and acetylcysteine solution for inhalation,while the control group was treated with piperacillin sodium tazobactam sodium for injection,ambroxol hydrochloride,budesonide suspension and acetylcysteine solution for inhalation.The levels inflammatory factors,peripheral blood WBC level,time of clinical symptoms disappearing and efficacy of the 2 groups were compared.Results:After treatment,TNF-α,CRP levels of the observation group and control group were lower than those before treatment(P<0.05),and the observation group was lower than the control group(P<0.05);after treatment,WBC,N%level of the observation group and control group was lower than before treatment(P<0.05);after treatment,the disappearance time of rales and the average healing time in the control group were longer than those in the observation group(P<0.05);the total effective rate of the observation group was 91.07%,which was higher than the control group of 75.24%(P<0.05).Conclusion:Shufeng Jiedu Capsules combined with conventional Western medicine can effectively inhibit the inflammatory response of patients with acute attack of chronic bronchitis with wind-heat attacking lung,playing a significant anti-infection role,improving clinical symptoms and promoting the recovery of the disease.
作者
费玲
赵秋良
张维维
FEI Ling;ZHAO Qiuliang;ZHANG Weiwei(Department of Respiratory Medicine,904th Hospital of the Joint Service Support Force of the Chinese People′s Liberation Army,Wuxi 214000,China)
出处
《世界中医药》
CAS
2020年第22期3439-3442,共4页
World Chinese Medicine
基金
江苏省卫生厅重点项目(H201435)。
