摘要
[目的]探讨溃疡性结肠炎患者肠道菌群分布、炎性因子水平及发病相关因素。[方法]选择2017-01-2019-01就诊的溃疡性结肠炎患者72例,纳入观察组;另选择同期68例健康体检者纳入对照组;对2组研究对象的肠道菌群分布、血清炎症因子水平进行对比分析,采用Logistic相关因素分析的方式探讨引起溃疡性结肠炎的相关危险因素。[结果]观察组患者血清白细胞介素-4明显低于对照组(P<0.05),血清白细胞介素-6、白细胞介素-17、白细胞介素-23以及肿瘤坏死因子-α水平均明显高于对照组(P<0.05),双歧杆菌、乳杆菌含量明显低于对照组(P<0.05),拟杆菌、肠杆菌、肠球菌以及梭杆菌含量明显高于对照组(P<0.05);经Logistic多因素分析表明吸烟为溃疡性结肠炎的保护性因素(P<0.05),饮酒、饮食不洁、情绪紧张、合并感染均为溃疡性结肠炎的独立危险因素(P<0.05)。[结论]溃疡性结肠炎患者血清炎症因子水平明显升高,肠内菌群存在失衡状况,给予高危因素者更多的关注健康知识教育,以期在更大程度上降低溃疡性结肠炎的发生率。
[Objective]To investigate the distribution of intestinal flora,inflammatory factors and pathogenesis related factors in patients with ulcerative colitis.[Methods]Seventy-two patients with ulcerative colitis from January 2017 to January 2019 were enrolled in the observation group,another 68 healthy subjects in our hospital were included in the control group.The intestinal flora distribution and serum inflammatory factor levels of the two groups were compared and analyzed.Logistic related factors were used to analyze the risk factors associated with ulcerative colitis.[Results]The serum IL-4 level in the observation group was significantly lower than that in the control group(P<0.05).The serum levels of IL-6,IL-17,IL-23 and TNF-αwere significantly higher in the observation group than in the control group(P<0.05).The content of Bifidobacterium and Lactobacillus was significantly lower than that of the control group(P<0.05).The content of Bacteroides,Enterobacter,Enterococcus and Fusobacterium was significantly higher than that of the control group(P<0.05).Smoking was a protective factor for ulcerative colitis(P<0.05).Drinking history,unclean diet,emotional stress,and co-infection were independent risk factors for ulcerative colitis(P<0.05).[Conclusion]The level of serum inflammatory factors in patients with ulcerative colitis is significantly increased,and there is an imbalance in the intestinal flora of patients.The high-risk factors are more concerned about health knowledge education,in order to reduce the incidence of ulcerative colitis to a greater extent.
作者
龚秀敏
詹玮
尹明
FONG Xiu-min;ZHAN Wei;YIN Ming(Department of Clinical Laboratory,Xiantao First People's Hospital Affiliated to Yangtzeu University,433000 Xiantao,Hubei,China;Anorectal Surgery,Affiliated Hospital of Guizhou Medical University,550004 Guiyang,Guizhou,China)
出处
《临床消化病杂志》
2020年第5期290-294,共5页
Chinese Journal of Clinical Gastroenterology
关键词
溃疡性结肠炎
肠道菌群
炎症反应
相关危险因素
ulcerative colitis
intestinal flora
inflammatory response
related risk factors
