摘要
【目的】评估利用T1Mapping(T1定量图谱)T1值测定体模钆塞酸二钠(Gd-EOB-DTPA)溶液浓度的准确性,确定较优的扫描序列。【方法】制备不同浓度(0.007-1.814 g/L)的Gd-EOB-DTPA溶液体模(n=12)并行MRI扫描。扫描序列包括T1加权(T1WI)序列(opp-phase、IR、SE、T1-fl2d、T1-vibe、T1-3D)及T1定量图谱(T1Mapping)序列(VIBE_Mapping、T1-tra-3D_Mapping、T1-fl2d_Mapping)。在T1WI中测量体模溶液Sp及同层参照物Sm,计算信噪比(SNR)(Sp/Sm)。在T1Mapping测量体模溶液T1p、同层参照物T1m,背景T1n,计算SNR=T1p/T1 n、对比噪声比(CNR)=|T1p-T1m|/T1n。【结果】除SE序列外(P=0.058),其余各序列测定的信号强度(SI)、相对信号强度(RSI)与对比剂浓度分布均呈正相关(P<0.05)。体模溶液T1值与Gd-EOB-DTPA浓度分布呈负相关,相关性均有统计学意义(P<0.05)。T1Mapping序列中,VIBE序列的SNR、CNR高于T1-tra-3D、T1-fl2d(P<0.05),T1-tra-3D与T1-fl2d的SNR、CNR差别无统计学意义(P>0.05)。【结论】T1Mapping软件可获得准确的T1值。VIBE序列所得T1Mapping图像质量高,扫描速度快,更适用于Gd-EOB-DTPA肝脏增强MR检查。
【Objective】To evaluate the accuracy of the T1Mapping sequence in determining the concentration of the Gd-EOB-DTPA solution by measuring the T1values of the phantom,and to determine a better scanning sequence.【Methods】Gd-EOB-DTPA solution phantom was prepared with different concentrations(0.007-1.814 g/L)for MRI scan⁃ning(n=12).Scanning sequences include T1weighted image(WI)sequences(opp-phase,IR,SE,T1-fl2d,T1-vibe,T1-3D)and T1Mapping sequences(VIBE_Mapping,T1-tra-3D_Mapping,T1-fl2d_Mapping).In T1WI,the signal intensity of the phantom solution(Sp)and that of the reference object(Sm)at the same level were measured,and the signal to noise ratio(SNR)(Sp/Sm)was calculated.In T1Mapping,the T1 values of the phantom solution(T1p),the reference at the same level(T1m)and the background(T1n)were measured respectively,and the SNR and contrast to noise ratio(CNR)were calculated(SNR=T1p/T1n,CNR=|T1p-T1m|/T1n).【Results】The signal intensity(SI)and relative signal intensity(RSI)determined by the conventional sequences were positively correlated with the concentration of Gd-EOB-DTPA(P<0.05),except for the SE sequence(P=0.058).The T1 values of the phantom were negatively corre⁃lated with the concentration of Gd-EOB-DTPA,with statistically significance(P<0.05).Among the T1Mapping sequences,the SNR and CNR of the VIBE sequence were higher than those of T1-tra-3D and T1-fl2d sequences(P<0.05).There was no statistically significant difference between T1-tra-3D and T1-fl2d sequences(P>0.05).【Conclusion】T1Mapping software can obtain accurate T1 values.The T1Mapping image obtained by the VIBE sequence has high quality and fast scanning speed,which is more suitable for Gd-EOB-DTPA enhanced MR examination of liver.
作者
董帜
冯艳青
王猛
蔡华崧
李子平
冯仕庭
彭振鹏
DONG Zhi;FENG Yan-qing;WANG Meng;CAI Hua-song;LI Zi-ping;FENG Shi-ting;PENG Zhen-peng(Department of Radiology,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China)
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2020年第6期867-874,共8页
Journal of Sun Yat-Sen University:Medical Sciences
基金
国家自然科学基金(81971684,81771908,81770654)。
