摘要
目的探讨双相障碍抑郁发作及单相抑郁症患者与血清脑源性神经营养因子(BDNF)、γ-氨基丁酸(GABA)、促甲状腺激素(TSH)水平的相关性。方法选择2018年1月至2020年3月期间我院收治的抑郁症(n=59)、双相障碍抑郁发作(n=51)患者及健康志愿者(n=50)作为研究对象。采用汉密尔顿抑郁量表(HAMD-17)、心境障碍问卷(MDQ)、32项轻躁狂症状清单(HCL-32)评估各组受试者抑郁、狂躁或轻狂躁状态,测定血清BDNF、GABA、TSH水平。结果①双相障碍抑郁组、抑郁症组患者HAMD-17得分高于对照组(P<0.05),双相障碍抑郁组MDQ、HCL-12得分高于抑郁症组(P<0.05)。②双相障碍抑郁组、抑郁症组患者血清BDNF、GABA水平低于对照组(P<0.05),双相障碍抑郁血清BDNF、GABA水平低于抑郁症组(P<0.05);双相障碍抑郁组患者血清TSH高于对照组及抑郁症组(P<0.05)。③双相障碍抑郁发作患者血清BDNF与HAMD-17、MDQ、HCL-12呈负相关(P<0.05),血清GABA与MDQ、HCL-12呈负相关(P<0.05)。结论抑郁症及双相障碍抑郁发作患者存在血清BDNF、GABA、TSH分泌的失衡,其中双相障碍抑郁发作患者失衡状态更为明显。
Objective To investigate the correlations of bipolar disorder depressive episode and unipolar depression with serum brain-derived neurotrophic factor(BDNF),γ-aminobutyric acid(GABA)and thyroid-stimulating hormone(TSH)levels.Methods Patients with depression(n=59)and bipolar disorder depressive episode(n=51)admitted to the hospital during the period from January 2018 to March 2020 and healthy volunteers(n=50)were enrolled in the study.The Hamilton Depression Scale(HAMD-17),Mood Disorder Questionnaire(MDQ)and 32-item Hypomanic Symptom List(HCL-32)were used to assess depressive,manic or hypomanic states of each group.Serum BDNF,GABA and TSH levels were determined.Results①HAMD-17 scores of bipolar disorder depression group and depression group were higher than those of control group(P<0.05).MDQ and HCL-12 scores of bipolar disorder depression group were higher than those of depression group(P<0.05).②Serum BDNF and GABA levels of bipolar disorder depression group and depression group were lower than those of control group(P<0.05),which were lower in bipolar disorder depression group than depression group(P<0.05).Serum TSH of bipolar disorder depression group was higher than that of control group or depression group(P<0.05).③Serum BDNF was negatively correlated with HAMD-17,MDQ and HCL-12 scores in patients with bipolar disorder depressive episode(P<0.05),and serum GABA was negatively correlated with MDQ and HCL-12 scores(P<0.05).Conclusion There is an imbalance in secretion of serum BDNF,GABA and TSH in patients with depression and bipolar disorder depressive episode,which is more obvious in patients with bipolar disorder depressive episode.
作者
李家君
张浪
李娟
LI Jia-jun;ZHANG Lang;LI Juan(Department of Acute Psychiatry,The Fourth People’s Hospital of Chengdu,Chengdu 610036,China)
出处
《中国实验诊断学》
2020年第11期1781-1784,共4页
Chinese Journal of Laboratory Diagnosis
关键词
双相障碍抑郁发作
抑郁症
脑源性神经营养因子
Γ-氨基丁酸
促甲状腺激素
Bipolar disorder depressive episode
Depression
Brain-derived neurotrophic factor
γ-aminobutyric acid
Thyroid stimulating hormone
