摘要
目的对小槐花(Desmodium caudatum DC.)茎的化学成分进行研究。方法综合运用大孔吸附树脂法、反复硅胶柱色谱、Sephadex LH-20柱色谱、MCI柱色谱、聚酰胺柱色谱、开放ODS柱色谱、制备型高效液相色谱、制备薄层等方法进行分离,通过多种波谱学数据分析进行结构鉴定。结果共分离得到15个单体化合物,分别为5′-甲氧基异落叶松脂醇-9-O-β-D-木糖苷(5′-methoxy-9-O-β-D-xylopyranosyl-(-)-isolariciresinol,1)、五味子苷(schizandriside,2)、南烛木糖苷(lyoniside,3)、3β,23,28-三羟基-12-烯-齐墩果烷(3β-olean-12-ene-3,23,28-triol,4)、黄槿酮D(3β,23,28-trihydroxy-12-oleanene 3β-caffeate,5)、黄槿酮A(3β,23,28-trihydroxy-12-oleanene 23-caffeate,6)、齐墩果酸(oleanolic acid,7)、白桦脂醇(betulin,8)、羽扇豆醇(lupeol,9)、4,4′-二苯甲烷二氨基甲酸甲酯(4,4′-diphenylmethane-bislmethy(carbamate),10)、去氢骆驼蓬碱(harmine,11)、烟酸(nicotinic acid,12)、香草酸(vanillic acid,13)、水杨酸(salicylic acid,14)、黑麦草内酯(loliolide,15)。结论化合物2、3、10、11为首次从山蚂蝗属植物中分离得到,7、9、12、13等4个化合物为首次从小槐花植物中分离得到。
Objective To study the chemical constituents from the stems of Desmodium caudatum.Methods The chemical constituents were isolated by means of repeated column chromatography on macroporous adsorptive resins,silica gel,Sephadex LH-20,MCI,ODS,and preparative-HPLC.Results On the basis of physico-chemical properties and spectroscopic analysis,15 compounds were identified as:5′-methoxy-9-O-β-D-xylopyranosyl-(-)-isolariciresinol(1),schizandriside(2),lyoniside(3),3β-olean-12-ene-3,23,28-triol(4),3β,23,28-trihydroxy-12-oleanene 3β-caffeate(5),3β,23,28-trihydroxy-12-oleanene 23-caffeate(6),oleanolic acid(7),betulin(8),lupeol(9),4,4′-diphenylmethane-bislmethy(carbamate)(10),harmine(11),nicotinic acid(12),vanillic acid(13),slicylic acid(14),loliolide(15),respectively.Conclusion Among them,compounds 2,3,10,and 11 are the first time isolated from genus Desmodium,and compounds 7,9,12 and 13 are the first time isolated from D.caudatum.
作者
张毅
华琼琼
孙伊维
周邵伯
孟大利
ZHANG Yi;HUA Qiongqiong;SUN Yiwei;ZHOU Shaobo;MENG Dali(Chongqing Institute for Food and Drug Control,Chongqing 401121,China;School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2020年第10期884-889,共6页
Journal of Shenyang Pharmaceutical University
关键词
小槐花
茎
化学成分
Desmodium caudatum
stem
chemical constituent
