摘要
目的探讨超声弹性应变率比值法联合血清血管内皮生长因子(VEGF)、原癌基因CerbB-2检测对乳腺结节良恶性的鉴别价值。方法选取2017年12月至2019年12月130例存在乳腺可疑结节患者为研究对象,经病理证实,其中良性病变60例,恶性病变70例。对比不同病变患者血清VEGF、CerbB-2水平、超声弹性应变率;ROC曲线分析超声弹性应变率联合血清VEGF、CerbB-2检测对乳腺结节良恶性的鉴别效能,比较恶性病变不同病理特征患者血清VEGF、CerbB-2水平的差异;Pearson相关分析超声弹性应变率与恶性结节患者血清VEGF、CerbB-2水平的相关性。结果恶性病变患者血清VEGF、CerbB-2水平及超声弹性应变率比值高于良性病变患者(P<0.01);联合检测鉴别诊断乳腺病变良恶性的ROC曲线下面积为0.855,大于血清VEGF(0.799)、CerbB-2(0.777)、超声弹性应变率(0.778)单独诊断;联合检测鉴别诊断的敏感度为78.57%,特异度为78.33%。不同分化程度、有无淋巴结转移恶性病变患者血清VEGF、CerbB-2水平相比差异有统计学意义(P<0.01);恶性结节患者超声弹性应变率与血清VEGF、CerbB-2水平呈正相关(r=0.527,0.556,P<0.05)。结论乳腺结节良恶性患者超声弹性应变率比值和血清VEGF、CerbB-2水平不同,联合检测鉴别病变类型具有较高应用价值,可为临床完善相关机制提供参考依据。
Objective To explore the value of ultrasound elastic strain rate combined with serum vascular endothelial growth factor(VEGF)and proto-oncogene CerbB-2 detection in the differentiation of breast nodules.Methods From December 2017 to December 2019,130 patients with suspicious breast nodules were selected,including 60 benign lesions and 70 malignant lesions.The serum VEGF,CerbB-2 levels and ultrasonic elastic strain rate in patients with different lesions were compared.The ratio of ultrasonic elastic strain rate combined with serum VEGF and CerbB-2 detection in the diagnosis of benign and malignant breast nodules by ROC curve.The differences of serum VEGF and CerbB-2 levels in patients with different pathological features of malignant lesions were compared.The correlation between ultrasonic elastic strain rate and serum VEGF and CerbB-2 levels of patients with malignant nodules was analyzed by Pearson correlation.Results Serum VEGF and CerbB-2 levels and ultrasound elastic strain rate of patients with malignant lesions were higher than those with benign lesions(P<0.01);the area under the ROC curve for differential diagnosis of benign and malignant breast lesions with combined detection was 0.855,which was greater than that diagnosed separately by serum VEGF(0.799)and CerbB-2(0.777),ultrasonic elastic strain rate(0.778);the sensitivity and the specificity of differential diagnosis was 78.57%,78.33%.There were significant differences in serum VEGF and CerbB-2 levels in malignant lesions patients with different levels of differentiation,with or without lymph node metastasis(P<0.01);ultrasound elastic strain rate was positively correlated with serum VEGF and CerbB-2 levels in patients with malignant nodules(r=0.527,0.556,P<0.05).Conclusions The ultrasound elastic strain rate,serum VEGF and CerbB-2 levels are different in patients with benign and malignant breast nodules.Combined detection to identify lesion types has high application value,which can provide a reference for clinical improvement of related mechanisms.
作者
段更勇
韩路
方开峰
DUAN Geng-yong;HAN Lu;FANG Kai-feng(Department of Ultrasound,General Hospital of Wanbei Coal Electricity Group,Suzhou,Anhui 234000,China)
出处
《中国临床研究》
CAS
2020年第11期1481-1485,共5页
Chinese Journal of Clinical Research
基金
安徽省科学技术厅公益性研究联动计划项目(1704f0804050)。
