摘要
目的研究多索茶碱联合桉柠蒎治疗慢性阻塞性肺疾病(COPD)急性发作期的疗效及对Toll样受体4(TLR4)-髓样分化因子88(MyD88)通路的调控作用。方法将确诊的120例急性发作期COPD患者随机均分为观察组和对照组,每组60例。2组患者均采用多索茶碱治疗,观察组患者在此基础上联合桉柠蒎治疗,2组患者均治疗8周。比较2组患者的治疗效果、心肺功能、血气指标、免疫功能、血清TLR4、MyD88水平以及不良反应。结果与对照组比较,观察组患者的治疗效果显著提升;治疗后,2组患者的心肺功能以及血气指标均显著改善,且观察组患者的无氧阈值(AT)显著高于对照组,二氧化碳通气当量斜率(VE/VCO_2)、酸碱度(pH)、二氧化碳分压(PCO_2)和碳酸氢根(HCO^-_3)显著低于对照组,2组患者的血清TLR4和MyD88水平均显著下降,且观察组患者的血清TLR4和MyD88水平均显著低于对照组;2组患者的免疫球蛋白A(IgA)、免疫球蛋白M(IgM)和免疫球蛋白G(IgG)均显著升高,且观察组患者的IgA、IgM和IgG显著高于对照组。结论多索茶碱联合桉柠蒎在COPD急性发作期患者的治疗中通过对TLR4-MyD88通路的显著下调,改善患者的临床症状,治疗效果显著。
Objective To study the therapeutic effect of doxofylline combined with eucalyptol,limonene and pinene(ELP)on chronic obstructive pulmonary disease(COPD)in acute attack stage and the regulatory effect on toll like receptor 4-myeloid differentiation factor 88(TLR4-MyD88)pathway.Methods 120 COPD patients diagnosed were randomly divided into the observation group and the control group,60 patients in each group.Both groups were treated with doxofylline,on the basis of which the observation group was treated with ELP,Both group were treated for 8 weeks.The therapeutic effect,cardiopulmonary function,blood gas index,immune function,serum TLR4,MyD88 and adverse reactions were compared between the 2 groups.Results Compared with the control group,the treatment effect of the observation group was significantly improved;after treatment,the cardiopulmonary function and blood gas index of the 2 groups were significantly improved,and the observation group was significantly higher than that of the control group,VE/VCO 2,pH,PCO 2,HCO-3 were significantly lower than that of the control group,the serum TLR4 and MyD88 levels of the 2 groups were significantly decreased,and the serum TLR4,MyD88 levels of the observation group were significantly lower than that of the control group,the immunoglobulin A(IgA),immunoglobulin M(IgM)and immunoglobulin G(IgG)of the 2 groups were significantly higher,and the IgA,IgM and IgG of the observation group were significantly higher than that of the control group.Conclusion In the treatment of COPD patients with acute exacerbation of COPD,doxofylline combined with ELP can significantly reduce the TLR4-MyD88 pathway,improve the clinical symptoms of patients,and have a significant therapeutic effect.
作者
夏晓玲
张艳
XIA Xiaoling;ZHANG Yan(Department of Respiratory Medicine,Hai′an Hospital of Traditional Chinese Medicine,Hai′an 226600,China;Intensive Care Ward of Hai′an People′s Hospital,Hai′an 226600,China)
出处
《西北药学杂志》
CAS
2020年第6期911-914,共4页
Northwest Pharmaceutical Journal
基金
南通大学临床医学专项(编号:2019HY008)。
关键词
多索茶碱
桉柠蒎
慢性阻塞性肺病
Toll样受体4-髓样分化因子88
doxofylline
eucalyptol,limonene and pinene
chronic obstructive pulmonary disease(COPD)
toll like receptor 4-myeloid differentiation factor 88(TLR4-MyD88)
