摘要
目的探讨对新生儿化脓性脑膜炎患儿采取美罗培南药物进行治疗后获得临床效果。方法将医院2017年9月—2020年1月收治的112例新生儿化脓性脑膜炎患儿数字奇偶法分组;治疗组(56例):采用头孢曲松钠联合美罗培南展开脑膜炎治疗;对照组(56例):采用头孢曲松钠展开脑膜炎治疗;就组间脑膜炎疗效数据、系列指标恢复时间、脑脊液白细胞计数以及用药总不良反应率展开对比。结果治疗组新生儿化脓性脑膜炎患儿用药总有效率(96.43%)明显高于对照组(78.57%)(P<0.05);治疗组新生儿化脓性脑膜炎患儿颅内压降低时间(2.13±0.43)d、止惊时间(1.15±0.25)d、退热时间(1.15±0.25)d、脑膜刺激征消失时间(5.15±0.23)d、意识状态恢复正常时间(5.15±0.16)d均明显短于对照组(P<0.05);治疗前,治疗组新生儿化脓性脑膜炎患儿脑脊液白细胞计数(16.16±6.96)×10^9/L同对照组(16.16±6.98)×10^9/L比较,差异不具有统计学意义(P>0.05);治疗后,治疗组脑脊液白细胞计数(8.59±1.23)×10^9/L明显低于对照组(12.75±4.56)×10^9/L(P<0.05);两组患儿用药不良反应体现为皮疹、肾损伤、腹泻以及呕吐几方面,最终发现治疗组新生儿化脓性脑膜炎患儿总不良反应发生率(8.93%)同对照组(1.79%)比较,差异不具有统计学意义(P>0.05)。结论美罗培南有效应用,可使得新生儿化脓性脑膜炎患儿于疗效、指标、脑脊液白细胞计数以及用药安全性方面均获得确切改善,最终实现新生儿化脓性脑膜炎患儿有效预后。
Objective To investigate the clinical effect of meropenem in the treatment of purulent meningitis in neonates.Methods 112 cases of neonatal suppurative meningitis admitted to our hospital from September 2017 to January 2020 were divided into groups by digital parity method.In the treatment group(56 cases),meningitis was treated with ceftriaxone sodium and meropenem.Control group(56 cases):treatment with ceftriaxone sodium for meningitis;The efficacy data,recovery time,cerebrospinal fluid white blood cell count and the rate of total adverse reactions were compared.Results The total effective rate(96.43%)in the treatment group was significantly higher than that in the control group(78.57%)(P<0.05).The reduction time of intracranial pressure(2.13±0.43)d,anticonvulsive time(1.15±0.25)d,antipyretic time(1.15±0.25)d,disappearance time of meningeal stimulation(5.15±0.23)d and normal recovery time of consciousness(5.15±0.16)d in the treatment group were significantly shorter than those in the control group(P<0.05).Before treatment,there was no significant difference in cerebrospinal fluid white blood cell count(16.16±6.96)×10^9/L between the treatment group and the control group(16.16±6.98)×10^9/L between the treatment group and the control group(P>0.05).After treatment,the white blood cell count(8.59±1.23)×10^9/L in the treatment group was significantly lower than that in the control group(12.75±4.56)×10^9/L(P<0.05).The adverse reactions in the two groups were rash,kidney injury,diarrhea and vomiting,and it was found that the total incidence of adverse reactions in the treatment group(8.93%)was not significantly different from that in the control group(1.79%)(P>0.05).Conclusion The effective application of meropenem can effectively improve the efficacy,index,cerebrospinal fluid white blood cell count and drug safety of neonatal patients with purulent meningitis,and finally realize the effective prognosis of neonatal patients with purulent meningitis.
作者
廖景文
LIAO Jingwen(Department of Pediatrics,Sanming First Hospital Affiliated to Fujian Medical University,Sanming Fujian 365000,China)
出处
《中国继续医学教育》
2020年第34期140-144,共5页
China Continuing Medical Education
关键词
美罗培南
新生儿化脓性脑膜炎
疗效
指标恢复时间
脑脊液白细胞计数
用药不良反应
meropenem
neonatal pyogenic meningitis
curative effect
index recovery time
cerebrospinal fluid white blood cell count
adverse drug reaction
