摘要
【目的】探讨宫颈癌术后舒芬太尼与氟比洛芬酯的平衡镇痛的镇痛效果。【方法】本院手术治疗的130例宫颈癌患者,随机分为两组,各65例,观察组采用舒芬太尼与氟比洛芬酯实施术后镇痛,对照组仅采用舒芬太尼镇痛;比校两组术后不同时间点的视觉模拟评分(VAS)、术后静脉自控镇痛泵(PCIA)按压次数、血清前列腺素氏(PGE2)、皮质醇(Cor)、β内啡肽(β-EP)、5-程色胺(5-HT)的水平。【结果】术后2〜48 h之间,观察组的VAS评分均低于对照组,且两组之间相比较差异均有显著性(P<0.05);观察组术后24 h、术后48 h及总体PCIA按压次数均低于对照组(P<0.05);术前两组患者的血清PGE2、5-HT、Cor、β-EP水平比较差异均无显著性(P>0.05);术后24 h观察组患者血清PGE2、5-HT、Cor、β-EP水平均低于对照组,且差异有显著性(P<0.05)。【结论】宫颈癌术后采用舒芬太尼与氟比洛芬酯的平衡镇痛具有较好的镇痛效果,能有效降低术后疼痛相关因子分泌。
【Objective】To explore the analgesic effect of balanced analgesia with sufentanil and flurbiprofen axetil on postoperative pain after cervical cancer surgery.【Methods】A total of 130 patients with cervical cancer who underwent sur-gical treatment in our hospital were randomly divided into two groups with 65 cases in each group.The observation group was treated with sufentanil and flurbiprofen axetil,while patients in the control group received sufentanil only for postoperative analgesia.Pain scores(VAS)at different time points after surgery,postoperative intravenous analgesia pump(PCIA)compressions,serum prostaglandin E2(PGE2),cortisol(Cor),beta endorphin(β-EP),and serotonin(5-HT)levels were compared between the two groups.【Results】During 12-48h after operation,the VAS scores of the observation group were lower than those of the control group,and the differences between the two groups were significant(P<0.05).At 24 and 48 hours after surgery,the total number of PCIA compressions in the observation group was lower than that in the control group(P<0.05).There were no significant differences in serum PGE2,5-HT,Cor andβ-EP levels between the two groups before surgery(P>0.05).The levels of serum PGE2,5-HT,Cor andβ-EP in the observation group at 24 hours after operation were lower than those in the control group(P<0.05).【ConcIusion】The balanced anal-gesia of sufentanil and flurbiprofen has a better analgesic effect after cervical cancer surgery,which can effectively reduce the secretion of postoperative pain related factors.
作者
韩琪
李凤玲
陈惠群
廖永强
谢海辉
HAN Qi;LI Feng-ling;CHEN Hui-qun(Department of Anesthesiology,Dong guan People's Hospital,Guangdong Province 523000)
出处
《医学临床研究》
CAS
2020年第11期1644-1646,共3页
Journal of Clinical Research
基金
2015年东莞市医疗卫生科技计划一般项目(编号:2015105101184)。
