摘要
目的分析乙肝病毒感染患者体内免疫调节和转归情况,并分析免疫调节与临床转归的关系。方法回顾性分析呼和浩特市2015年1月至2018年12月间633份HBV感染疫情资料,同期选择内蒙古医科大学附属医院健康体检者作为对照组,检测HBV感染和健康者血中免疫细胞调节因子和淋巴细胞亚群,并统计一年临床转归结果,采用多元logistics回归分析免疫细胞调节因子和淋巴细胞与患者临床转归关系。结果HBV感染者血中CD4^+T细胞、CD8^+T细胞、NK细胞、IL-2、IL-12水平显著低于对照组,且随着患者临床转归结果恶化而显著降低(P<0.05);HBV感染者血中IL-4、IL-10水平显著高于对照组,且随着患者临床转归结果恶化而显著升高(P<0.05);HBV感染者与健康者血中INF-γ、B细胞及CD4^+/CD8^+水平差异无统计学意义(P>0.05);血中低CD4^+T细胞、低CD8^+T细胞、低NK细胞、低IL-2、低IL-12、高IL-4和高IL-10是导致患者临床转归恶化的独立性威胁因素(P<0.05)。结论HBV感染患者体内免疫调节处于抑制状态,且患者免疫抑制状态是影响患者临床转归质量的独立性影响因素。
Objective To investigate the immune regulation and prognosis of hepatitis B virus(HBV)infection in infected patients,and to analyze the relationship between immune regulation and clinical outcome.Methods The data of 633 cases of HBV infection in Huhhot from January 2015 to December 2018 were retrospectively analyzed.At the same time,healthy people from the Affiliated Hospital of Inner Mongolia Medical University were selected as the control group.Immune cell regulatory factors and lymphocyte subsets in blood of HBV infected and healthy people were tested.The results of one-year clinical outcomes were calculated.The relationship between immune cell regulatory factors and lymphocytes and the clinical outcomes of patients was analyzed by multiple logistics regression.Results The levels of CD4^+T cells,CD8^+T cells,NK cells,IL-2,and IL-12 in the blood of patients with HBV infection were significantly lower than those in the control group,and decreased as the patients’clinical outcome deteriorated(P<0.05).The levels of IL-4 and IL-10 in the blood of patients with HBV infection were significantly higher than those in the control group,and increased significantly with the deterioration of the clinical outcome of the patients(P<0.05).There was no significant difference in the levels of INF-γ,B cells and CD4^+/CD8^+between the two groups(P>0.05).Low CD4^+T cells,low CD8^+T cells,low NK cells,low IL-2,low IL-12,high IL-4 and high IL-10 were independent risk factors leading to the deterioration of clinical outcomes(P<0.05).Conclusion The immune regulation of patients with HBV infection is in a state of suppression,which is an independent factor affecting the clinical outcome of patients.
作者
娜丽
赵文江
马臻
李琳琳
NA Li;ZHAO Wenjiang;MA Zhen;LI Linlin(Department of infection,Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia 010050,China;Department of Pediatrics,Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia 010050,China)
出处
《公共卫生与预防医学》
2020年第6期117-120,共4页
Journal of Public Health and Preventive Medicine
基金
内蒙古医科大学青年创新基金项目(YKD2018QNCX)。
关键词
慢性乙肝病毒感染
免疫调节
转归
Chronic hepatitis B virus infection
Immune regulation
Outcome
