摘要
核酸适体是通过体外筛选技术得到的可特异性结合靶标分子的单链寡核苷酸分子探针,其表现出与抗体相当或更优异的特异性和亲和力,且具有靶标范围广、免疫原性低、易于精准制备和修饰及设计灵活可控等优势.为癌症的早期筛查、诊断及靶向治疗提供了全新的分子工具,在癌症诊疗领域获得了广泛的关注与应用.本文聚焦核酸适体在癌症诊断及治疗中的应用,对近年来取得的研究进展进行了系统性总结,并对未来发展方向及前景进行了展望.
Aptamers are single-stranded oligonucleotides selected through a process known as Systematic Evo⁃lution of Ligands by Exponential enrichment(SELEX),showing a high selectivity towards their target mole⁃cules.The selectivity and affinity of aptamers are comparable to antibodies and even higher.They have the advantages of multiple targets,low immunogenicity,ease of accurate synthesis and modification,flexible and controllable design,which endow them as new molecular tools for early screening,diagnosis and targeting therapy.Therefore,aptamers have attracted extensive attention and have been applied in the field of cancer diagnosis and treatment.This review focused on the applications of aptamers in cancer diagnosis and treat⁃ment,and summarized systematically the research progresses made in recent years and discussed the prospec⁃tive of the future development.
作者
董倩
李兆倩
彭天欢
陈卓
谭蔚泓
DONG Qian;LI Zhaoqian;PENG Tianhuan;CHEN Zhuo;TAN Weihong(State Key Laboratory of Chemo/Bio-Sensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China;Hunan Key Laboratory of Molecular Science and Biomedicine Laboratory,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China;Institute of Molecular Medicine(IMM),Renji Hospital,School of Medicine,College of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200127,China;Institute of Cancer and Basic Medicine(IBMC),Chinese Academy of Sciences,The Cancer Hospital of the University of Chinese Academy of Sciences,Hangzhou 310022,China)
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2020年第12期2648-2657,共10页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:21522501)
湖南省自然科学基金(批准号:2018JJ1007)资助.
关键词
核酸适体
靶向治疗
分子探针
癌症诊断与治疗
Aptamer
Targeting therapy
Molecular probe
Cancer diagnosis and treatment
