摘要
目的研究胸腺肽α1治疗对2型糖尿病合并肺结核患者痰菌转阴及免疫应答的影响。方法前瞻性选择2018年9月至2019年12月期间在宁德师范学院附属宁德市医院就诊的2型糖尿病合并肺结核患者,按照随机数字表法分为接受抗结核药物治疗的对照组、抗结核药物联合胸腺肽α1治疗的观察组。比较2组痰菌转阴、病灶吸收情况及治疗前、治疗后6个月时外周血T细胞及自然杀伤(NK)细胞、血清免疫细胞因子[干扰素-γ(IFN-γ)、白细胞介素(IL)-2、IL-4、IL-5]的差异。结果观察组治疗后的痰菌转阴及病灶吸收有效率分别为78.13%和87.50%,均明显高于对照组的51.13%和62.50%,差异有统计学意义(P<0.05);与治疗前比较,2组治疗后6个月时的外周血CD3^+T细胞、CD4^+T细胞、NK细胞数目及血清IFN-γ、IL-2含量均明显升高,外周血CD8^+T细胞数目及血清IL-4、IL-5含量明显下降,且观察组治疗后6个月的外周血CD3^+T细胞(67.72±9.48 vs.59.68±8.34)%、CD4^+T细胞(45.65±6.24 vs.37.31±5.77)%、NK细胞(12.37±1.75 vs.9.12±1.13)%数目及血清IFN-γ(77.72±9.45 vs.46.52±7.23)pg/mL、IL-2(56.72±7.82 vs.26.76±4.47)pg/mL含量均明显高于对照组,外周血CD8^+T细胞(22.74±4.42 vs.26.65±4.85)%数目及血清IL-4(17.64±2.75 vs.23.32±3.84)pg/mL、IL-5(13.26±1.88 vs.18.47±2.67)pg/mL含量明显低于对照组,差异有统计学意义(P<0.05)。结论胸腺肽α1用于2型糖尿病合并肺结核治疗能够促进痰菌转阴及病灶吸收、改善机体免疫功能。
Objective To study the effect of thymosinα1 therapy on sputum negative transformation and immune response in type 2 diabetic patients with pulmonary tuberculosis.Methods Patients with type 2 diabetes mellitus complicated with pulmonary tuberculosis who were treated in Ningde City Hospital Affiliated to Ningde Normal University from September 2018 to December 2019 were prospectively selected and randomly divided into control group receiving anti-tuberculosis drugs and observation group receiving anti-tuberculosis drugs combined with thymosinα1 treatment.The differences of sputum negative transformation and focus absorption,peripheral blood T cells and NK cells,serum immunocytokines[interferon-γ(IFN-γ),interleukin(IL)-2,IL-4,IL-5]before treatment and 6 months after treatment between the two groups were compared.Results After treatment,the sputum negative rate and the effective rate of lesion absorption in the observation group were 78.13%and 87.50%,which were significantly higher than 51.13%and 62.50%in the control group,the differences were statistically significant(P<0.05);6 months after treatment,the number of CD3^+T cells(67.72±9.48 vs.59.68±8.34)%,CD4^+T cells(45.65±6.24 vs.37.31±5.77)%,NK cells(12.37±1.75 vs.9.12±1.13)%in the peripheral blood and IFN-γ(77.72±9.45 vs.46.52±7.23)pg/mL,IL-2(56.72±7.82 vs.26.76±4.47)pg/mL levels in serum of two groups were significantly increased,the number of CD8^+T cells(22.74±4.42 vs.26.65±4.85)%in the peripheral blood and IL-4(17.64±2.75 vs.23.32±3.84)pg/mL,IL-5(13.26±1.88 vs.18.47±2.67)pg/mL levels in serum were significantly decreased and the number of CD3^+T cells,CD4^+T cells,NK cells in the peripheral blood and IFN-γ,IL-2 levels in serum of observation group were significantly higher than those of control group,the number of CD8^+T cells in the peripheral blood and IL-4,IL-5 levels in serum were significantly lower than those of control group,the differences were statistically significant(P<0.05).Conclusion Thymosinα1 in the treatment of patients with type 2 diabetes mellitus complicated with pulmonary tuberculosis can promote sputum negative transformation,focus absorption and improve immune function.
作者
姚慧娟
姚昆
林厚雄
褚静宇
YAO Hui-juan;YAO Kun;LIN Hou-xiong(Department of Infectious Diseases,Ningde City Hospital Affiliated to Ningde Normal University,Ningde Fujian 352100,China;Department of Emergency,Ningde City Hospital Affiliated to Ningde Normal University,Ningde Fujian 352100,China)
出处
《临床和实验医学杂志》
2020年第24期2637-2640,共4页
Journal of Clinical and Experimental Medicine
基金
福建省自然科学基金项目(编号:2016J01575)。
关键词
2型糖尿病
肺结核
胸腺肽Α1
免疫功能
Type 2 diabetes mellitus
Tuberculosis
Thymosinα1
Immune function
