摘要
传染病是一种由致病性微生物引起,能够影响人类身体健康甚至引发严重社会危机的传播性疾病。近年来,新冠、埃博拉等传染病的恶性暴发促使人们寻找更为高效便捷的防治手段以遏制疾病的进程。抗体在传染病防治中的应用引起了广泛关注,palivizumab是目前唯一被批准应用于呼吸道合胞病毒在免疫力低下人群的预防的单克隆抗体。纳米抗体(nano-antibody,Nb)是目前已知的能与抗原稳定结合的最小功能性单域抗体,具有稳定性高、亲水性强、易于表达和改造等优势。独特的分子特性使其在病毒、细菌、寄生虫等引发的传染病的预防、诊断和治疗中展现出良好的应用前景,相关研究显示纳米抗体对艾滋、流感、新型冠状病毒等都有很好的治疗效果。重点叙述纳米抗体的结构特点及其在传染性疾病中的研究进展。
Infectious disease mainly refer to transmissible diseases caused by pathogenic microorganisms.It can affect human health and even cause serious social crisis.In recent years,the outbreaks of infectious diseases like COVID-19 and ebola have prompted people to seek more efficient and convenient means to control and prevent infectious diseases.As an effective way currently,antibody has drawn people’s attention.However,palivizumab,for the prevention and treatment of respiratory syncytial virus,is the only one monoclonal antibody approved for infectious diseases.Nano-antibody(Nb)is the smallest known functional antibody capable of stably binding to antigens.Nb has the advantages of high stability,strong hydrophilicity,easy production through microbial systems,easy modification,etc.Due to its unique molecular properties,Nb has shown promising application prospects in the prevention,diagnosis and treatment of infectious diseases caused by viruses,bacteria,parasites,etc.Related studies have shown that Nb has good therapeutic effects on AIDS,influenza,novel coronavirus,etc.This paper focuses on the structural characteristics of Nb and its research progress in infectious diseases.
作者
梅雅贤
王玥
罗文新
MEI Ya-xian;WANG Yue;LUO Wen-xin(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&National Institute of Diagnostics and Vaccine Development in Infectious Disease,School of Public Health,Xiamen University,Xiamen 361102,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2020年第10期24-34,共11页
China Biotechnology
基金
国家自然科学基金(31870925)资助项目。
关键词
传染性疾病
纳米抗体
预防
诊断
治疗
Infectious diseases
Nano-antibody
Prevention
Diagnosis
Treatment
