摘要
1例67岁女性患者为预防动脉硬化性心血管疾病自行口服阿司匹林肠溶片100 mg、3次/d。42 d后出现便血,并进行性加重,导致严重出血性贫血(红细胞计数1.55×1012/L、血红蛋白47 g/L);血压下降至58/33 mmHg(1 mmHg=0.133 kPa)。出血第4天行剖腹探查术,诊断为结肠出血,行肠系膜动脉结扎术后出血停止。患者未经专业医师进行获益和出血风险的评估自行服用阿司匹林,日剂量超过推荐剂量,导致严重下消化道出血,住院手术治疗,属于H级用药错误。
A 67-year-old female patient took aspirin enteric-coated tablets 100mg thrice daily orally in order to prevent arteriosclerotic cardiovascular disease without doctor*s advice.After 42 days of medication,the patient developed hematochezia,which was progressively aggravated and fin ally led to severe hemorrhagic anemia(red blood cell count 1.55×1O12/L,hemoglobin 47 g/L)and decreased blood pressure(58/33 mmHg).On the 4th day of bleeding,exploratory laparotomy was performed and colonic hemorrhage was diagnosed.Ligation of the mesenteric artery was performed and the patient's bleeding stopped.The patient took aspirin by herself at a daily dose exceeding the recommended dose without assessment of ben efits and bleeding risks by professional physicians and developed severe lower gastrointestinal hemorrhage,which led to hospitalization and surgical treatment.It was a grade H medication error.
作者
张洁婷
杨海
庄雪梅
于迪
Zhang Jieting;Yang Hai;Zhuang Xuemei;Yu Di(Department of Pharmacy,Qingdao Central Hospital,Shandong Province,Qingdao 266042;Department of Pharmacy,First Affiliated Hospital of Soochou University,Jiangsu Province,Suzhou 215006)
出处
《药物不良反应杂志》
CSCD
2020年第11期638-639,共2页
Adverse Drug Reactions Journal
基金
青岛中医药科研计划(2019-zyy033,2020-zyy027)
青岛市医药科研计划(2019-WJZD063)。
关键词
阿司匹林
用药错误
胃肠出血
Aspirin
Medication errors
Gastrointestinal hemorrhage
