摘要
目的探究阿立哌唑用于利培酮所致高催乳素血症的最佳剂量,为临床合理用药提供参考依据。方法选取2018年3月至2019年4月在辽宁省复员军人康宁医院接受治疗的57例利培酮所致高催乳素血症患者为研究对象,依据随机数字分组法将研究对象分为A、B、C 3组(每组19例);3组均采用阿立哌唑治疗,A组剂量为5 mg,B组剂量为10 mg,C组为15 mg。测量3组患者不同时间节点(治疗前、治疗6周、治疗12周)的血清泌乳素水平,采用不良反应量表对3组患者在用药治疗期间的不良反应发生率进行比较。结果3组患者在治疗前的血清泌乳素水平无统计学意义(P>0.05),用药治疗后第6周、第12周进行检测时,3组患者在血清泌乳素水平均有着明显的下降,治疗前后相比组间具有统计学意义(P<0.05);3组患者在用药治疗期间均无严重不良事件发生(P>0.05),用药治疗后,A组、B组不良反应评分均显著低于C组,差异有统计学意义(P<0.05),但A组与B组患者的不良反应评分无统计学意义(P>0.05)。结论阿立哌唑治疗利培酮所引起的高催乳素血症临床效果显著,其中以5~10 mg为最佳剂量,大剂量(15 mg)会增加不良反应发生率。
Objective To explore the optimal dosage of aripiprazole for risperidone-induced hyperprolactinemia,and to provide reference for clinical rational drug use.Methods From March 2018 to April 2019,57 patients with hyperprolactinemia caused by risperidone who were treated in our hospital were selected as the study subjects.According to the random number grouping method,the study subjects were divided into groups A,B and C(19 cases in each group);all three groups were treated with aripiprazole,with the dose of 5 mg in group A,10 mg in group B and 15 mg in group C.Serum prolactin levels were measured at diff erent time points(before treatment,6 weeks after treatment,12 weeks after treatment)in the three groups of patients,and the incidence of adverse reactions in the three groups of patients during treatment was compared with the adverse reaction scale.Result There was no signifi cant diff erence in serum prolactin levels among the three groups before and after treatment(P>0.05).When the serum prolactin levels were measured at the 6th and 12th weeks after treatment,there was a signifi cant decrease in the serum prolactin levels among the three groups before and after treatment,which was statistically signifi cant(P<0.05).There were no serious adverse events in the three groups during treatment(P>0.05).The adverse reaction scores of group A and group B were signifi cantly lower than those of group C,the diff erence was statistically signifi cant(P<0.05),but the adverse reaction scores of group A and group B were not statistically signifi cant(P>0.05).Conclusion Aripiprazole has a signifi cant clinical eff ect in the treatment of hyperprolactinemia caused by risperidone,in which 5-10 mg is the best dose,and a large dose(15 mg)will increase the incidence of adverse reactions.
作者
田歌
TIAN Ge(The 7^th Ward,Kangning Hospital for Demobilized Soldiers in Liaoning Province,Xingcheng 125100,China)
出处
《中国医药指南》
2020年第32期83-84,共2页
Guide of China Medicine
关键词
高泌乳素血症
阿立哌唑
利培酮
临床效果
临床合理用药
Hyperprolactinemia
Aripiprazole
Risperidone
Clinical eff ect
Clinical rational drug use
